Planned preoperative radiation therapy vs. definitive radiotherapy for advanced laryngeal carcinoma

In the period 1970-1980 inclusive, 191 patients with T3T4 laryngeal carcinoma (glottic: 63 and supraglottic: 128) received either definitive radiation therapy (RT) (60-65 Gy in 6-7 weeks) or planned preoperative radiation therapy (25 Gy in 5 equal daily fractions of 5 Gy) followed by laryngectomy wi...

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Bibliographic Details
Published inThe Laryngoscope Vol. 94; no. 10; p. 1355
Main Authors Kazem, I, van den Broek, P
Format Journal Article
LanguageEnglish
Published United States 01.10.1984
Subjects
Cobalt Radioisotopes - therapeutic use
Combined Modality Therapy
Humans
Laryngeal Neoplasms - pathology
Laryngeal Neoplasms - radiotherapy
Laryngeal Neoplasms - surgery
Laryngectomy
Neck Dissection
Neoplasm Staging
Prognosis
Radioisotope Teletherapy
Radiotherapy Dosage
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Summary:In the period 1970-1980 inclusive, 191 patients with T3T4 laryngeal carcinoma (glottic: 63 and supraglottic: 128) received either definitive radiation therapy (RT) (60-65 Gy in 6-7 weeks) or planned preoperative radiation therapy (25 Gy in 5 equal daily fractions of 5 Gy) followed by laryngectomy with or without neck dissection (RT + S). Selection for RT vs. RT + S was based on medical operability and/or patient's refusal to undergo surgery. All patients are evaluable with minimum of 2 years observation. Crude 5 and 10-year survival probability for 32 patients with glottic localization who received RT is 55% and 38% vs. 65% and 65% respectively for 31 treated with RT + S. For 52 patients with supraglottic site who received RT, the 5 and 10-year survival is 44% and 44% vs. 82% and 60% for 76 patients treated with RT + S.
ISSN:0023-852X
1531-4995
DOI:10.1288/00005537-198410000-00017