Why haven't we made an efficacious vaccine for malaria?

The malaria parasite has an extraordinary ability to evade the immune system, which may explain the failure of malaria vaccines to date. It is high time to think seriously of new treatments for this disease.

Saved in:
Bibliographic Details
Published inEMBO reports Vol. 14; no. 8; p. 661
Main Author Wykes, Michelle N
Format Journal Article
LanguageEnglish
Published Chichester, UK John Wiley & Sons, Ltd 01.08.2013
Nature Publishing Group UK
Blackwell Publishing Ltd
Nature Publishing Group
Subjects
Antibodies, Protozoan - blood
Antibodies, Protozoan - immunology
B-Lymphocytes - immunology
B-Lymphocytes - parasitology
Dendritic Cells - immunology
Dendritic Cells - parasitology
EMBO19
EMBO23
Humans
Immune Evasion
Immunologic Memory
Malaria
Malaria Vaccines - immunology
Malaria, Falciparum - immunology
Malaria, Falciparum - parasitology
Malaria, Falciparum - prevention & control
Opinion
Parasites
Plasmodium falciparum - immunology
Plasmodium falciparum - pathogenicity
Treatment Failure
Upfront
Vaccines
Vector-borne diseases
Online AccessGet full text

Cover

More Information
Summary:The malaria parasite has an extraordinary ability to evade the immune system, which may explain the failure of malaria vaccines to date. It is high time to think seriously of new treatments for this disease.
Bibliography:ArticleID:EMBR2013103
ark:/67375/WNG-BS25TC13-B
istex:4D50F090B734C8972234E5CC918A085BDFA3886A
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Michelle N Wykes is at The Queensland Institute of Medical Research, Queensland, Australia. E-mail: michelle.wykes@qimr.edu.au
ISSN:1469-221X
1469-3178
DOI:10.1038/embor.2013.103