胰高血糖素样肽-1对骨代谢的影响和潜在机制

胰高血糖素样肽-1（glucagon-like peptide-1,GLP-1）受体激动剂作为新型2型糖尿病治疗药物,其对骨代谢的影响受到广泛关注。本文综述了GLP-1对骨代谢的影响及其潜在机制：增加骨密度和改善骨质量,并可能通过促进骨形成、抑制骨吸收和影响两者间的偶联机制而发挥作用。...

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Bibliographic Details
Published in复旦学报（医学版） Vol. 44; no. 3; pp. 369 - 373
Main Author 赵辰荷 梁璟 杨吟秋 于明香
Format Journal Article
LanguageChinese
Published 复旦大学附属中山医院内分泌科 上海200032 2017
Subjects
糖尿病
胰高血糖素样肽1
骨生成
骨质吸收
骨质疏松
骨质疏松
胰高血糖素样肽1
骨质吸收
glucagon-like peptide-1
bone resorption
骨生成
diabetes mellitus
osteogenesis
糖尿病
osteoporosis
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ISSN1672-8467
DOI10.3969/j.issn.1672-8467.2017.03.020

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Summary:胰高血糖素样肽-1（glucagon-like peptide-1,GLP-1）受体激动剂作为新型2型糖尿病治疗药物,其对骨代谢的影响受到广泛关注。本文综述了GLP-1对骨代谢的影响及其潜在机制：增加骨密度和改善骨质量,并可能通过促进骨形成、抑制骨吸收和影响两者间的偶联机制而发挥作用。
Bibliography:glucagon-like peptide-1 ; osteogenesis ; bone resorption ; osteoporosis ; diabetes mellitus
Glucagon-like peptide-1 （GLP-1） receptor agonists are a novel type of drugs for type 2 diabetes mellitus （T2DM）, and its impact on bone metabolism has drawn great attention nowadays. This review reveals the impact and potential mechanism of GLP-1 on bone metabolism：GLP-1 enhances bone mineral density and improves bone quality and it may act on bone by promoting bone formation, inhibiting bone resorption and affecting the coupling mechanism of them in order to play its role in bone metabolism.
31-1885/R
ZHAO Chen-he, LIANG Jing, YANG Yin-qiu, YU Ming-xiang （Departznent of Endocrinology, Zhongshan Hospital, Fudan University, Shanghai 200032, China）
ISSN:1672-8467
DOI:10.3969/j.issn.1672-8467.2017.03.020