Involvement of Chromosome X in Primary Cytogenetic Change in Human Neoplasia: Nonrandom Translocation in Synovial Sarcoma

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 84; no. 7; pp. 1981 - 1985
• Main Authors: Turc-Carel, C., Cin, P. Dal, Limon, J., Rao, U., Li, F. P., Corson, J. M., Zimmerman, R., Parry, D. M., Cowan, J. M., Sandberg, A. A.
• Format: Journal Article
• Language: English
• Published: Washington, DC National Academy of Sciences of the United States of America 01.04.1987; National Acad Sciences
• Subjects: Adolescent; Adult; Biological and medical sciences; Bone Neoplasms - genetics; Bone Neoplasms - pathology; Cancer; Cell physiology; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes; Cells, Cultured; Chromosome Banding; Chromosome translocation; Chromosomes; Cytogenetics; Female; Fundamental and applied biological sciences. Psychology; Histiocytoma, Benign Fibrous - genetics; Histiocytoma, Benign Fibrous - pathology; Humans; Karyotyping; Keratins; Male; Malignant fibrous histiocytoma; Middle Aged; Molecular and cellular biology; Sarcoma; Sarcoma - genetics; Sarcoma - pathology; Soft tissue neoplasms; Synovial Membrane - pathology; Synovial sarcoma; Translocation, Genetic; Tumors; X Chromosome; Chromosomal aberration; Human; Cell culture; Cytogenetics; Abnormal chromosome; Tumor; X-Chromosome; Carcinogenesis; Tumor cell; Chromosome translocation
• ISSN: 0027-8424; 1091-6490
• DOI: 10.1073/pnas.84.7.1981

A translocation that involves chromosome X (band p11.2) and chromosome 18 (band q11.2) was observed in short-term in vitro cultures of cells from five synovial sarcomas and one malignant fibrous histiocytoma. In four of these tumors, the translocation t(X;18)(p11.2;q11.2) was reciprocal. The two other tumors had complex translocations: t(X;18;21)(p11.2;q11.2;p13) and t(X;15;18)(p11.2;q23;q11.2). A translocation between chromosomes X and 18 was not detected in other histological types of soft tissue sarcoma. The X;18 rearrangement appears to characterize the synovial sarcoma and is the first description of a primary, nonrandom change in the sex chromosome of a human solid tumor.