Loureirin A Promotes Cell Differentiation and Suppresses Migration and Invasion of Melanoma Cells via WNT and AKT/mTOR Signaling Pathways

• Published in: Biological & pharmaceutical bulletin Vol. 47; no. 2; pp. 486 - 498
• Main Authors: Ma, Quan, Li, Bo-han, Xia, Zi-yi, Wang, Guo-li, Li, De-fang, Liu, Ling, Wang, Xue-li, Zheng, Qiu-sheng, Shi, Dan, Li, Min-jing, Kuok, Chiu-fai, Liu, Xiao-na, Cheng, Xiao-yang
• Format: Journal Article
• Language: English
• Published: Japan The Pharmaceutical Society of Japan 22.02.2024; Japan Science and Technology Agency
• Subjects: AKT protein; Cell cycle; Cell Differentiation; Cell Line, Tumor; Cell migration; Cell Movement; Cell Proliferation; Chalcones; Humans; invasion; Kinases; Loureirin A; Melanin; Melanoma; Melanoma - metabolism; migration; Proto-Oncogene Proteins c-akt - metabolism; Rapamycin; Signal transduction; TOR protein; TOR Serine-Threonine Kinases - metabolism; Traditional Chinese medicine; Tumors; Wnt protein; Wnt Signaling Pathway; migration; melanoma; cell differentiation; invasion; Loureirin A
• ISSN: 0918-6158; 1347-5215; 1347-5215
• DOI: 10.1248/bpb.b23-00415

Resina Draconis is a traditional Chinese medicine, with the in-depth research, its medicinal value in anti-tumor has been revealed. Loureirin A is extracted from Resina Draconis, however, research on the anti-tumor efficacy of Loureirin A is rare. Herein, we investigated the function of Loureirin A in melanoma. Our research demonstrated that Loureirin A inhibited the proliferation of and caused G0/G1 cell cycle arrest in melanoma cells in a concentration-dependent manner. Further study showed that the melanin content and tyrosinase activity was enhanced after Loureirin A treatment, demonstrated that Loureirin A promoted melanoma cell differentiation, which was accompanied with the reduce of WNT signaling pathway. Meanwhile, we found that Loureirin A suppressed the migration and invasion of melanoma cells through the protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway. Taken together, this study demonstrated for the first time the anti-tumor effects of Loureirin A in melanoma cells, which provided a novel therapeutic strategy against melanoma.