Region-Specific Expression of Two Mouse Homeo Box Genes

• Published in: Science (American Association for the Advancement of Science) Vol. 235; no. 4794; pp. 1379 - 1382
• Main Authors: Utset, Manuel F., Awgulewitsch, Alexander, Ruddle, Frank H., McGinnis, William
• Format: Journal Article
• Language: English
• Published: Washington, DC The American Association for the Advancement of Science 13.03.1987; American Association for the Advancement of Science
• Subjects: Animals; Animals, Newborn - genetics; Base Sequence; Biological and medical sciences; Brain - metabolism; Cell Differentiation; Central nervous system; Drosophila; Drosophila melanogaster - genetics; Embryos; Fetus - metabolism; Fundamental and applied biological sciences. Psychology; Gene expression; Gene Expression Regulation; Genes; Genes, Homeobox; Genetic aspects; Genetics; Hindbrain; House mouse; In situ hybridization; Magnification; Medical research; Mice; Molecular and cellular biology; Molecular genetics; Morphogenesis; Nervous system; Nucleic Acid Hybridization; RNA; Spinal cord; Spinal Cord - metabolism; Spine; Transcription, Genetic; Vertebrata; Specificity; Mammalia; Gene; Mouse; Rodentia; Gene expression
• ISSN: 0036-8075; 1095-9203
• DOI: 10.1126/science.2881353

Mammalian homeo box genes have been identified on the basis of sequence homology to Drosophila homeotic and segmentation genes. These studies examine the distribution of transcripts from two mouse homeo box genes, Hox-2.1 and Hox-3.1, throughout the latter third of prenatal development. Transcripts from these genes are regionally localized along the rostro-caudal axis of the developing central nervous system, yielding expression patterns very similar to patterns of Drosophila homeotic gene expression.