Refractory Primary Vitreoretinal Lymphoma Involving the Spinal Cord with a Temporary Complete Response to Tirabrutinib

• Published in: Internal Medicine Vol. 62; no. 3; pp. 459 - 463
• Main Authors: Iizuka-Honma, Hiroko, Takizawa, Haruko, Mitsumori, Toru, Okura, Hidehiro, Ishii, Hisato, Noguchi, Masaaki
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society of Internal Medicine 01.02.2023; Japan Science and Technology Agency
• Subjects: Case Report; Central nervous system; Central Nervous System Neoplasms - pathology; Chemotherapy; Humans; Internal medicine; Lymphoma; Lymphoma - diagnosis; Methotrexate; primary vitreoretinal lymphoma; Radiation therapy; Retinal Neoplasms - diagnosis; Retinal Neoplasms - pathology; Retinal Neoplasms - therapy; Spinal cord; Spinal Cord - pathology; tirabrutinib; Vitreous Body - pathology; tirabrutinib; primary vitreoretinal lymphoma; spinal cord
• ISSN: 0918-2918; 1349-7235
• DOI: 10.2169/internalmedicine.9591-22

Many patients with primary vitreoretinal lymphoma (PVRL) exhibit central nervous system (CNS) involvement either at the diagnosis or during follow-up. The prognosis in the patients of PVRL with relapsed or refractory CNS remains extremely poor. We herein report a patient with refractory PVRL who had recurrence in the spinal cord despite receiving high-dose methotrexate-based chemotherapy and whole-brain radiotherapy. The patient surprisingly responded to tirabrutinib temporarily. We believe that this case suggests the utility of this new target therapy.