Voltammetric Behavior of the Transfer of Mono- and Polyammonium Ions across a Phospholipid Monolayer at the Nitrobenzene/Water Interface
The influence of a phospholipid, dipalmitoyl phosphatidylcholine, layer at a nitrobenzene|water interface on the transfer of tetraethylammonium ion and a polyammonium anti-fungus agent, poly[(dimethylimino)(2-oxo-1,2-ethanediyl)imino-1,6-hexanediylimino(1-oxo-1,2-ethanediyl)(dimethylimino)-1,6-hexan...
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Published in | Analytical Sciences Vol. 21; no. 12; pp. 1529 - 1531 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Japan
The Japan Society for Analytical Chemistry
2005
Japan Science and Technology Agency |
Online Access | Get full text |
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Summary: | The influence of a phospholipid, dipalmitoyl phosphatidylcholine, layer at a nitrobenzene|water interface on the transfer of tetraethylammonium ion and a polyammonium anti-fungus agent, poly[(dimethylimino)(2-oxo-1,2-ethanediyl)imino-1,6-hexanediylimino(1-oxo-1,2-ethanediyl)(dimethylimino)-1,6-hexanediyl] ion, across the interface was studied by normal pulse voltammetry. When the phospholipid was adsorbed to form a monolayer at the nitrobenzene|water interface by its addition to the organic phase, the half-wave potential in the current vs. potential curves for the transfer of tetraethylammonium ion did not change, but the limiting current was significantly decreased at certain sampling times, indicating a retarding effect of the layer on the ion-transfer. On the other hand, in the current vs. potential curves for the transfer of the polyammonium ion, no significant change in either the half-wave potential or the limiting current was observed upon adding the phospholipid, indicating that the polyammonium ion can easily permeate through the phospholipid layer. The results suggest a new application of the voltammetric technique to the study of cell membrane permeability to polyionic bioactive compounds. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0910-6340 1348-2246 |
DOI: | 10.2116/analsci.21.1529 |