IgG4-related Sclerosing Cholangitis Complicated with Cholangiocarcinoma and Detected by Forkhead Box P3 Immunohistochemical Staining
An 80-year-old man was admitted due to biliary stricture with autoimmune pancreatitis. Although radiographical examinations suggested Immunoglobulin G4-related sclerosing cholangitis (IgG4-SC), punched biopsies from the bile duct revealed adenocarcinoma. In the resected specimen, abundant N-terminus...
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Published in | Internal Medicine Vol. 60; no. 6; pp. 859 - 866 |
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Main Authors | , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Japan
The Japanese Society of Internal Medicine
15.03.2021
Japan Science and Technology Agency |
Subjects | |
Online Access | Get full text |
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Summary: | An 80-year-old man was admitted due to biliary stricture with autoimmune pancreatitis. Although radiographical examinations suggested Immunoglobulin G4-related sclerosing cholangitis (IgG4-SC), punched biopsies from the bile duct revealed adenocarcinoma. In the resected specimen, abundant N-terminus of Forkhead box P3 (Foxp3)-positive cells were localized in cholangiocarcinoma (CCA) tissue, while IgG4-positive cells were spread around the entire bile duct. Therefore, the case was diagnosed with IgG4-SC accompanied by CCA, not sporadic CCA. We herein report an informative case wherein IgG4-positive cells were abundant in CCA tissue and Foxp3 immunohistochemical staining allowed us to determine that this case had two entities. |
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Bibliography: | ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3 Correspondence to Dr. Katsuyuki Miyabe, kmiyabe@nagoya2.jrc.or.jp |
ISSN: | 0918-2918 1349-7235 |
DOI: | 10.2169/internalmedicine.5920-20 |