Genetic polymorphisms of metabolic enzymes—CYP1A1, CYP2D6, GSTM1, and GSTT1, and gastric carcinoma susceptibility
Genetic polymorphisms in metabolic enzymes are associated with numerous cancers. In this study, the relationships between genetic polymorphisms of phase I metabolic enzymes including cytochrome P450 1A1 (CYP1A1), CYP2D6 and phase II metabolic enzymes such as glutathione S -transferase M1 (GSTM1) and...
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Published in | Tumor biology Vol. 32; no. 1; pp. 215 - 222 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Dordrecht
Springer Netherlands
01.02.2011
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | Genetic polymorphisms in metabolic enzymes are associated with numerous cancers. In this study, the relationships between genetic polymorphisms of phase I metabolic enzymes including cytochrome P450 1A1 (CYP1A1), CYP2D6 and phase II metabolic enzymes such as glutathione
S
-transferase M1 (GSTM1) and GSTT1 and gastric carcinoma susceptibility were investigated. Genomic DNA was isolated from the peripheral blood of 129 healthy controls and 123 gastric carcinoma patients from Han ethnic group of Hunan Province located in Central South China. The genetic polymorphisms of the above mentioned enzymes were analyzed using PCR-RFLP techniques. There was no significant difference among the frequencies of
CYP1A1
and/or
CYP2D6
gene’s wild type, heterozygous or homozygous mutations between the gastric carcinoma group and control group. But the differences among the frequencies of
GSTM1
and
GSTT1
null genotype between the gastric carcinoma and control group were significant (both
P
< 0.05). Also there were significant differences in the frequencies of
GSTM1
null in high/high–middle differentiated, middle differentiated, middle–low differentiated and low differentiated gastric tumor separately.
GSTM1
null showed an increased risk in middle–low differentiated and low differentiated gastric carcinoma type, but
GSTT1
null was not a risk factor for the four pathological types of gastric carcinoma mentioned above. We report here that the genotypes of
CYP1A1
and
CYP2D6
are not associated with gastric carcinoma risk;
GSTM1
null, but not
GSTT1
null inheritably increases risk of some pathological types of gastric carcinoma in Han ethnic population of Hunan Province. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1010-4283 1423-0380 |
DOI: | 10.1007/s13277-010-0115-8 |