Severe Hypomagnesemia Associated with the Long-term Use of the Potassium-competitive Acid Blocker Vonoprazan

Hypomagnesemia caused by a proton pump inhibitor (PPI) was first reported in 2006. We herein report a case of hypomagnesemia due to the long-term use of vonoprazan, a potassium-competitive acid blocker (P-CAB). A 66-year-old man was admitted to our hospital complaining of disturbance of consciousnes...

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Published inInternal Medicine Vol. 61; no. 1; pp. 119 - 122
Main Authors Okamoto, Masaru, Wakunami, Yu, Hashimoto, Kyoji
Format Journal Article
LanguageEnglish
Published Japan The Japanese Society of Internal Medicine 01.01.2022
Japan Science and Technology Agency
Subjects
Aged
Case Report
Case reports
Humans
Hypomagnesemia
Internal medicine
Male
Potassium
potassium-competitive acid blocker
Proton pump inhibitors
Proton Pump Inhibitors - adverse effects
Protons
Pyrroles - adverse effects
Sulfonamides - adverse effects
vonoprazan
hypomagnesemia
vonoprazan
potassium-competitive acid blocker
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Summary:Hypomagnesemia caused by a proton pump inhibitor (PPI) was first reported in 2006. We herein report a case of hypomagnesemia due to the long-term use of vonoprazan, a potassium-competitive acid blocker (P-CAB). A 66-year-old man was admitted to our hospital complaining of disturbance of consciousness with evidence of hypomagnesemia noted on blood testing. The long-term use of vonoprazan was considered the cause of his hypomagnesemia, so it was discontinued, after which the hypomagnesemia improved. Hypomagnesemia can be induced not only by PPI treatment but also following the long-term use of P-CAB.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ObjectType-Report-1
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Correspondence to Dr.　Masaru Okamoto, okamotoma@tp-ch.jp
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.7325-21