Impact of chronic morphine on delta opioid receptor-expressing neurons in the mouse hippocampus

• Published in: Neuroscience Vol. 313; pp. 46 - 56
• Main Authors: Erbs, E, Faget, L, Ceredig, R.A, Matifas, A, Vonesch, J.-L, Kieffer, B.L, Massotte, D
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 28.01.2016; Elsevier - International Brain Research Organization
• Subjects: abstinence; Animals; Chronic Disease; chronic morphine; delta opioid receptor; Disease Models, Animal; Female; G protein-coupled receptor; Gene Knock-In Techniques; Green Fluorescent Proteins - genetics; Green Fluorescent Proteins - metabolism; hippocampus; Hippocampus - drug effects; Hippocampus - metabolism; Hippocampus - pathology; Immunohistochemistry; Life Sciences; Male; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Transgenic; Morphine - pharmacology; Morphine Dependence - metabolism; Morphine Dependence - pathology; Narcotics - pharmacology; Neurology; Neurons - drug effects; Neurons - metabolism; Neurons - pathology; Neurons and Cognition; Pharmaceutical sciences; Receptors, Opioid, delta - genetics; Receptors, Opioid, delta - metabolism; Toxicology; G protein-coupled receptor; DG; mu opioid; DOP; hippocampus; delta opioid receptor; MOP; dentate gyrus; delta opioid; DOP receptor in fusion with the enhanced green fluorescent protein; abstinence; DOP-eGFP; chronic morphine
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2015.10.022

Highlights • Chronic morphine decreases the density of delta receptor-expressing neurons. • Chronic morphine equally affects all delta opioid receptor-expressing populations. • Chronic morphine increases cell surface expression of delta opioid receptors. • Mu opioid receptors are required to observe chronic morphine effects. • Most changes induced by chronic morphine persist after four weeks of abstinence.