Effects of Pro-Hyp, a Collagen Hydrolysate-Derived Peptide, on Hyaluronic Acid Synthesis Using in Vitro Cultured Synovium Cells and Oral Ingestion of Collagen Hydrolysates in a Guinea Pig Model of Osteoarthritis

• Published in: Bioscience, biotechnology, and biochemistry Vol. 74; no. 10; pp. 2096 - 2099
• Main Authors: OHARA, Hiroki, IIDA, Hiroyuki, ITO, Kyoko, TAKEUCHI, Yasuo, NOMURA, Yoshihiro
• Format: Journal Article
• Language: English
• Published: Tokyo Japan Society for Bioscience, Biotechnology, and Agrochemistry 2010; Japan Society for Bioscience Biotechnology and Agrochemistry; Oxford University Press
• Subjects: Animals; Biological and medical sciences; Cells, Cultured; Collagen - metabolism; collagen hydrolysates; Dipeptides - administration & dosage; Dipeptides - metabolism; Dipeptides - pharmacology; Dipeptides - therapeutic use; Disease Models, Animal; Dose-Response Relationship, Drug; Eating; Fundamental and applied biological sciences. Psychology; Guinea Pigs; hyaluronic acid; Hyaluronic Acid - biosynthesis; Hydrolysis; Male; osteoarthritis; Osteoarthritis - drug therapy; Osteoarthritis - metabolism; proline-hydroxyproline (Pro-Hyp); proteoglycan; Synovial Membrane - cytology; Synovial Membrane - drug effects; Synovial Membrane - metabolism; Proteoglycan; Cell culture; Peptides; collagen hydrolysates; Hydroxyproline; Rodentia; Proline; In vitro; proline-hydroxyproline (Pro-Hyp); Vertebrata; Mammalia; Guinea pig; Hydrolysate; Collagen; Models; Hyaluronic acid; Osteoarthritis
• ISSN: 0916-8451; 1347-6947; 1347-6947
• DOI: 10.1271/bbb.100193

Proline-hydroxyproline (Pro-Hyp) stimulated hyaluronic acid production in cultured synovium cells. It was detected in guinea pig blood after oral ingestion of collagen hydrolysates. Oral administration of collagen hydrolysates increased the amount of proteoglycans in the epiphyses. It also reduced the morphological changes associated with osteoarthritic cartilage destruction of the knee joint. The results suggest that collagen hydrolysates have therapeutic potential for treatment of osteoarthritis.