The role of polyomaviruses in human disease

Abstract The human polyomaviruses, BK virus and JC virus, have long been associated with serious diseases including polyomavirus nephropathy and progressive multifocal leukoencephalopathy. Both viruses establish ubiquitous, persistent infections in healthy individuals. Reactivation can occur when th...

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Published inVirology (New York, N.Y.) Vol. 384; no. 2; pp. 266 - 273
Main Authors Jiang, Mengxi, Abend, Johanna R, Johnson, Silas F, Imperiale, Michael J
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 20.02.2009
Subjects
BK virus
BK Virus - pathogenicity
BKV
Humans
Infectious Disease
JC virus
JC Virus - pathogenicity
JCV
Kidney Diseases - virology
Leukoencephalopathy, Progressive Multifocal - virology
MCV
Multiple Sclerosis - virology
Neoplasms - virology
PML
Polyomavirus
Polyomavirus - classification
Polyomavirus - pathogenicity
Polyomavirus Infections - transmission
Polyomavirus Infections - virology
Polyomavirus nephropathy
Tumor Virus Infections - virology
MCV
Polyomavirus nephropathy
Polyomavirus
JCV
BKV
PML
KI
WU
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Summary:Abstract The human polyomaviruses, BK virus and JC virus, have long been associated with serious diseases including polyomavirus nephropathy and progressive multifocal leukoencephalopathy. Both viruses establish ubiquitous, persistent infections in healthy individuals. Reactivation can occur when the immune system is impaired, leading to disease progression. Recently, the human polyomavirus family has expanded with the identification of three new viruses (KI, WU and Merkel cell polyomavirus), all of which may prove to be involved in human disease. This review describes the general aspects of human polyomavirus infections and pathogenicity. Current topics of investigation and future directions in the field are also discussed.
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These authors contributed equally.
ISSN:0042-6822
1096-0341
DOI:10.1016/j.virol.2008.09.027