Vasopressin for Refractory Hypotension in Extremely Low Birth Weight Infants

• Published in: The Journal of pediatrics Vol. 157; no. 3; pp. 502 - 504
• Main Authors: Bidegain, Margarita, MD, MHS-CL, Greenberg, Rachel, MD, Simmons, Catherine, MSN, NNP, Dang, Chi, PharmD, Cotten, C. Michael, MD, MHS, Smith, P. Brian, MD, MHS, MPH
• Format: Journal Article
• Language: English
• Published: Maryland Heights, MO Elsevier Inc 01.09.2010; Elsevier
• Subjects: Arterial hypertension. Arterial hypotension; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Clinical manifestations. Epidemiology. Investigative techniques. Etiology; Diseases of mother, fetus and pregnancy; General aspects; Gynecology. Andrology. Obstetrics; Humans; Hypotension - drug therapy; Infant, Extremely Low Birth Weight; Infant, Newborn; Medical sciences; Pediatrics; Pregnancy. Fetus. Placenta; Vasopressins - therapeutic use; Mean blood pressure; Necrotizing enterocolitis; Extremely low birth weight; MBP; ELBW; NEC; Human; Premature; Pediatrics; Treatment resistance; Pregnancy disorders; Cardiovascular disease; Infant; Extremely low birthweight; Neuropeptide; Vasopressin; Very low birthweight; Refractory; Newborn diseases; Prematurity; Arterial hypotension; Neurohypophyseal hormone
• ISSN: 0022-3476; 1097-6833
• DOI: 10.1016/j.jpeds.2010.04.038

Intravenous vasopressin at 0.01 to 0.04 units/kg/h increased median mean blood pressure from 26 mm Hg (range 18-44) to 41 mm Hg (range 17-90) by 12 hours of infusion ( P = .002) and allowed weaning of catecholamines in a group of extremely low birth weight infants with refractory hypotension.