Vascular Health in Adults Born After Using Assisted Reproductive Technologies

An increasing number of children are conceived by assisted reproductive technologies (ART). Several studies indicated vascular alterations in ART children. However, limited data is available within the adult ART population. Therefore, this study investigated the overall vascular health of young ART...

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Published inPediatric Cardiology Vol. 45; no. 6; pp. 1242 - 1250
Main Authors Langer, Magdalena, Vilsmaier, Theresa, Kramer, Marie, Sciuk, Franziska, Kolbinger, Brenda, Li, Pengzhu, Jakob, Andre, Rogenhofer, Nina, Dalla-Pozza, Robert, Thaler, Christian, Haas, Nikolaus Alexander, Oberhoffer, Felix Sebastian
Format Journal Article
LanguageEnglish
Published New York Springer Science and Business Media LLC 01.08.2024
Springer US
Springer
Subjects
Adults
Analysis
Blood lipids
Cardiac Surgery
Cardiology
Medicine
Medicine & Public Health
Original
Original Article
Reproductive technology
Vascular Surgery
Germany
Blood pressure
Endothelial function
Arterial stiffness
Vascular health
Assisted reproductive technologies
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Summary:An increasing number of children are conceived by assisted reproductive technologies (ART). Several studies indicated vascular alterations in ART children. However, limited data is available within the adult ART population. Therefore, this study investigated the overall vascular health of young ART adults in comparison to spontaneously conceived peers. In total, 16 ART subjects and 22 spontaneously conceived peers (22.06 ± 2.21 years vs. 22.00 ± 2.14 years, p  = 0.194) were enrolled for the assessment of endothelial function, brachial blood pressure, central blood pressure, pulse wave velocity, carotid intima-media thickness, and blood lipids. No significant differences in vascular function were detected between the in vitro fertilization subgroup ( n  = 9), the intracytoplasmic sperm injection subgroup ( n  = 7) and spontaneously conceived peers. This pilot study suggests an unimpaired vascular function in young ART adults. In the future, multi-centric studies with a greater sample size are required to confirm the results of the current study and enable precise cardiovascular risk stratification of the adult ART population.
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ISSN:0172-0643
1432-1971
1432-1971
DOI:10.1007/s00246-022-03050-4