Draft genome sequences of two super-extensively drug-resistant isolates of Mycobacterium tuberculosis from China

• Published in: FEMS microbiology letters Vol. 347; no. 2; pp. 93 - 96
• Main Authors: Lin, Nan, Liu, Zhangyi, Zhou, Jie, Wang, Shihua, Fleming, Joy
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.10.2013; Wiley-Blackwell; Oxford University Press
• Subjects: Bacteriology; Biological and medical sciences; China; DNA, Bacterial - genetics; Drug resistance; Extensively Drug-Resistant Tuberculosis - microbiology; Fundamental and applied biological sciences. Psychology; Genetic diversity; Genetic Variation; Genome, Bacterial - genetics; Microbiology; Miscellaneous; Molecular Sequence Data; multidrug resistance; Mutation; Mycobacterium tuberculosis; Mycobacterium tuberculosis - genetics; Polymorphism, Single Nucleotide; single nucleotide polymorphisms; Tuberculosis; whole genome shotgun sequencing; Asia; China; multidrug resistance; whole genome shotgun sequencing; single nucleotide polymorphisms; tuberculosis; Nucleotide sequence; Mycobacterium tuberculosis; Mycobacteriales; Multiple resistance; Mycobacteriaceae; Bacteria; Isolate; Actinomycetes; Single nucleotide polymorphism; Genome
• ISSN: 0378-1097; 1574-6968
• DOI: 10.1111/1574-6968.12238

Abstract The prevalence of drug-resistance in Mycobacterium tuberculosis is already having a negative impact on the control of tuberculosis. We report the draft genome sequences of two super-extensively drug-resistant M. tuberculosis isolates from China, FJ05194 (lineage 2) and GuangZ0019 (lineage 4), and compare them with the H37Rv reference strain to identify possible sources of genetic variation associated with their extensive drug resistance. Our results suggest that their extensive drug resistance probably results from the stepwise accumulation of resistances to individual drugs.