Myopathy of the upper airway in snoring and obstructive sleep apnea

• Published in: Laryngoscope investigative otolaryngology Vol. 7; no. 2; pp. 636 - 645
• Main Authors: Shah, Farhan, Stål, Per
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.04.2022; Wiley
• Subjects: Airway management; Antibodies; Binding sites; Body mass index; desmin; Laboratories; Mouth; muscle pathology; myopathy; obstructive sleep apnea; Original Research; protein-aggregates; Sleep apnea; Sleep Medicine and Science; Surgery; United Kingdom > UK; United States > US; Sweden; obstructive sleep apnea; desmin; protein‐aggregates; myopathy; muscle pathology
• ISSN: 2378-8038; 2378-8038
• DOI: 10.1002/lio2.782

Objective Previous reports of muscle changes in the upper airways of obstructive sleep apnea (OSA) patients have primarily been attributed to acquired nerve lesions due to snoring vibrations. The aim of this study was to investigate whether alterations reflecting muscle fiber injuries also occur in the upper respiratory tract of snoring and OSA patients and if these changes relate to upper airway dysfunction. Methods Muscle changes in biopsies from the soft palate of 20 patients suffering from snoring and OSA were investigated with enzyme, immunohistochemical, and morphometric techniques. Biopsies from eight healthy non‐snoring subjects were used as controls. Swallowing dysfunction was assessed with videoradiography. Results Fourteen patients had various degrees of swallowing dysfunction. The muscle samples from all the patients showed changes typical for both motor‐nerve lesions and muscle fiber injuries. The most common alterations reflecting myopathy were fibers having aggregates and disorganization of cytoskeletal proteins (15.5 ± 10.7%). Other changes were fibers with vacuole‐like structures (5.0 ± 4.4%), centrally positioned myonuclei (7.9 ± 4.8%), subsarcolemmal accumulations of nuclei, and various forms and sizes of ring fibers, that is, fibers where the myofilaments were disorganized peripherally (2.8 ± 2.8%). Conclusion The results show that muscle changes mirroring both myopathy and neuropathy co‐exist in the upper airway of snoring OSA patients. These findings suggest muscle weakness as a contributing factor to the upper airway dysfunction in OSA patients.