骨髓间充质干细胞在视网膜移植领域的研究进展

临床上对于视网膜退行性疾病的治疗仍然只停留在改善循环、营养神经等支持治疗阶段,缺少特效的治疗方法,骨髓间充质干细胞（bone mesenchymal stem cells,BMSCs）是具有较强自我复制功能和多向分化潜能的一类细胞,人们开始通过尝试不同的分离、诱导、移植等手段,以实现其向视网膜细胞的转化,并最终实现体内的替代治疗。我们就BMSCs在视网膜移植领域的研究进展进行综述,以期为进一步的研究提供参考。...

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Bibliographic Details
Published in国际眼科杂志 Vol. 13; no. 1; pp. 79 - 81
Main Author 徐志刚 吕淑慧 穆敬中 张雪岩 齐艳秀 朱金玲
Format Journal Article
LanguageChinese
Published 佳木斯大学附属第一医院眼科,中国黑龙江省佳木斯市,154002 2013
Subjects
光感受器样细胞
视网膜神经样细胞
骨髓间充质干细胞
骨髓间充质干细胞
视网膜神经样细胞
光感受器样细胞
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Summary:临床上对于视网膜退行性疾病的治疗仍然只停留在改善循环、营养神经等支持治疗阶段,缺少特效的治疗方法,骨髓间充质干细胞（bone mesenchymal stem cells,BMSCs）是具有较强自我复制功能和多向分化潜能的一类细胞,人们开始通过尝试不同的分离、诱导、移植等手段,以实现其向视网膜细胞的转化,并最终实现体内的替代治疗。我们就BMSCs在视网膜移植领域的研究进展进行综述,以期为进一步的研究提供参考。
Bibliography:Nowadays,treatments for retinal degenerative diseases mainly stay in supportive treatments such as improve circulation,nourishing nerve in the clinical.It still lacks effective treatment.As bone marrow mesenchymal stem cells（BMSCs） have high expansion potential and autologous immunological characteristics,people have tried various ways of isolation,induction,transplantation and so on,with a purpose to transform BMSCs to retinal nerve cells,and ultimately make cell-replaced therapy available.We reviewed the current literature for trials and case reports on retina transplantation of BMSCs,to provide help for the further research.
bone marrow mesenchymal stem cells; retinal nerve-like cells; photoreceptor-like cell
61-1419/R
Zhi-Gang Xu,Shu-Hui Lü,Jing-Zhong Mu,Xue-Yan Zhang,Yan-Xiu Qi,Jin-Ling Zhu Department of Ophthalmology,the First Affiliated Hospital of Jia Mu Si University,Jiamusi 154002,Heilongjiang Province,China
ISSN:1672-5123
DOI:10.3980/j.issn.1672-5123.2013.01.19