HBV感染与复制模型的建立及应用

乙型肝炎是危害人类健康的重要传染病,目前的抗病毒治疗,如干扰素、核苷和核苷酸类药物仍无法治愈慢性乙型肝炎。因此,亟待阐明HBV复制和致病机制,探索新的治疗靶点,进而研发新的治疗药物或方案。合适的HBV感染与复制模型是上述研究的基础。由于HBV具有严格的种属限制性及组织亲嗜性,使得HBV感染与复制模型的研发受到一定限制。在国家传染病科技重大专项资助下,国内研究者建立了一系列的细胞和动物模型,就此并结合近年来国内外研究进展进行简要综述。...

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Published in临床肝胆病杂志 Vol. 33; no. 8; pp. 1458 - 1464
Main Author 王宝菊 朱彬 郭伟娜 杨东亮
Format Journal Article
LanguageChinese
Published 华中科技大学同济医学院附属协和医院感染病科,武汉,430022 2017
Subjects
疾病模型,动物
细胞模型
肝炎病毒,乙型
细胞模型
肝炎病毒,乙型
hepatitis B virus
cell model
disease models,animal
疾病模型,动物
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ISSN1001-5256
DOI10.3969/j.issn.1001-5256.2017.08.009

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Summary:乙型肝炎是危害人类健康的重要传染病,目前的抗病毒治疗,如干扰素、核苷和核苷酸类药物仍无法治愈慢性乙型肝炎。因此,亟待阐明HBV复制和致病机制,探索新的治疗靶点,进而研发新的治疗药物或方案。合适的HBV感染与复制模型是上述研究的基础。由于HBV具有严格的种属限制性及组织亲嗜性,使得HBV感染与复制模型的研发受到一定限制。在国家传染病科技重大专项资助下,国内研究者建立了一系列的细胞和动物模型,就此并结合近年来国内外研究进展进行简要综述。
Bibliography:WANG Baoju, ZHU Bin, GUO Weina, et al. （Department of Infectious Diseases, Union Hospital Affiliated to Tongji Medical College of Hua- zhong University of Science and Technology, Wuhan 430022 , China）
hepatitis B virus; cell model; disease models; animal
Hepatitis B is still an important infectious disease which threatens human health,and current antiviral therapy,including interferon and nucleos（ t） ide analogues,cannot cure chronic hepatitis B. Therefore,it is urgent to explore the detail mechanisms of HBV replication and pathogenesis,identify new therapeutic targets,and develop new drugs or treatment regimens,which relies on the development of suitable models for HBV infection and replication. Species restriction and tissue tropism of HBV have limited the development of models for HBV infection and replication. With the support by National Science and Technology Major Project for Infectious Diseases,the researchers in China have developed a series of cellular and animal models for HBV. This article reviews t
ISSN:1001-5256
DOI:10.3969/j.issn.1001-5256.2017.08.009