Reduction of plasma aldosterone and arterial stiffness in obese pre- and stage1 hypertensive subjects after aerobic exercise

• Published in: Journal of human hypertension Vol. 29; no. 1; pp. 53 - 57
• Main Authors: Collier, S R, Sandberg, K, Moody, A M, Frechette, V, Curry, C D, Ji, H, Gowdar, R, Chaudhuri, D, Meucci, M
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.01.2015; Nature Publishing Group
• Subjects: 692/699/2743/393; 692/699/75/243; 692/700/565; Aerobic exercises; Aerobics; Aldosterone; Aldosterone - blood; Angiotensin; Biomarkers - blood; Blood Pressure; Body mass index; Body weight; Care and treatment; Down-Regulation; Epidemiology; Exercise; Exercise Therapy; Female; Health Administration; Health aspects; Humans; Hypertension; Hypertension - blood; Hypertension - diagnosis; Hypertension - physiopathology; Hypertension - therapy; Male; Medicine; Medicine & Public Health; Middle Aged; Obesity; Obesity - blood; Obesity - diagnosis; Obesity - physiopathology; Obesity - therapy; original-article; Oxygen Consumption; Patient outcomes; Physical fitness; Physical training; Prehypertension - blood; Prehypertension - diagnosis; Prehypertension - physiopathology; Prehypertension - therapy; Prospective Studies; Public Health; Pulse Wave Analysis; Renin; Time Factors; Treatment Outcome; Vascular Stiffness; United States
• ISSN: 0950-9240; 1476-5527; 1476-5527
• DOI: 10.1038/jhh.2014.33

Obesity-related hypertension is associated with increased activity of the renin-angiotensin-aldosterone system (RAAS), increasing arterial stiffness. Aerobic exercise decreases pulse wave velocity (PWV), therefore a treatment option for hypertension and obesity. Assess RAAS activity and PWV before and after 4 weeks of aerobic training in unmedicated, pre-to-stage-1 hypertensives. Ten obese subjects (52±3.2 years, body mass index=33.5±1.4) performed 30 min of aerobic exercise on a treadmill 3 days per week at 65% of peak oxygen consumption (VO 2peak ). Descriptive characteristics, systolic and diastolic blood pressure (SBP and DBP), PWV, and a blood draw was performed at baseline, following the 4-week control and training interventions. No differences in descriptive characteristics during the control period were observed, however, a significant decrease in plasma aldosterone (ALDO) (255.4±75 to 215.8±66 pg ml −1 , P =0.001), SBP (140±12 to 136±10.4 mm Hg; P =0.02), DBP (89±4.2 to 85±6.3 mm Hg; P =0.03) and central PWV (11.2±0.6 to 9.8±0.8 m s −1 ; P =0.04) was shown pre-to-post exercise training. Four weeks of moderate-intensity aerobic training in obese, hypertensives decreases plasma ALDO independently of body weight and is significantly correlated to decreases in PWV reductions.