To control floating drug delivery system in a simulated gastric environment by adjusting the Shell layer formulation
Gastroretentive drug delivery system (GDDS) are novel systems that have been recently developed for treating stomach diseases. The key function of all GDDS systems is to control the retention time in the stomach. However, research into the bulk density or entanglement of polymers, especially regardi...
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Published in | Biomaterials research Vol. 25; no. 1; pp. 1 - 31 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
London
BioMed Central Ltd
09.10.2021
BioMed Central American Association for the Advancement of Science (AAAS) 한국생체재료학회 |
Subjects | |
Online Access | Get full text |
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Summary: | Gastroretentive drug delivery system (GDDS) are novel systems that have been recently developed for treating stomach diseases. The key function of all GDDS systems is to control the retention time in the stomach. However, research into the bulk density or entanglement of polymers, especially regarding their effects on drug float and release times, is scarce. In this research, we prepared the floating core-shell beads carrying tetracycline. The ratio of chitosan and xanthan gum in the shell layer was changed to modify polymer compactness. Tetracycline was encapsulated in the alginate core. Using scanning electron microscopy (SEM) techniques, we observed that the shell formulation did not change the bead morphology. The cross-sectional images showed that the beads were highly porous. The interaction between anionic xanthan gum and cationic chitosan made the shell layer dense, resisting to the mass transfer in the shell layer. Due to the high mass transfer resistance to water penetration, the longer float and delivery time were caused by the dense surface of the beads. The cell culture demonstrated that floating core-shell beads were biocompatible. Importantly, the beads with tetracycline showed a significant prolonged anti-bacterial effect. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 https://biomaterialsres.biomedcentral.com/track/pdf/10.1186/s40824-021-00234-6.pdf |
ISSN: | 2055-7124 1226-4601 2055-7124 |
DOI: | 10.1186/s40824-021-00234-6 |