Genome-wide Association and Follow-Up Replication Studies Identified ADAMTS18 and TGFBR3 as Bone Mass Candidate Genes in Different Ethnic Groups
To identify and validate genes associated with bone mineral density (BMD), which is a prominent osteoporosis risk factor, we tested 379,319 SNPs in 1000 unrelated white U.S. subjects for associations with BMD. For replication, we genotyped the most significant SNPs in 593 white U.S. families (1972 s...
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| Published in | American journal of human genetics Vol. 84; no. 3; pp. 388 - 398 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Cambridge, MA
Elsevier Inc
13.03.2009
Cell Press Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0002-9297 1537-6605 |
| DOI | 10.1016/j.ajhg.2009.01.025 |
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| Abstract | To identify and validate genes associated with bone mineral density (BMD), which is a prominent osteoporosis risk factor, we tested 379,319 SNPs in 1000 unrelated white U.S. subjects for associations with BMD. For replication, we genotyped the most significant SNPs in 593 white U.S. families (1972 subjects), a Chinese hip fracture (HF) sample (350 cases, 350 controls), a Chinese BMD sample (2955 subjects), and a Tobago cohort of African ancestry (908 males). Publicly available Framingham genome-wide association study (GWAS) data (2953 whites) were also used for
in silico replication. The GWAS detected two BMD candidate genes,
ADAMTS18 (ADAM metallopeptidase with thrombospondin type 1 motif, 18) and
TGFBR3 (transforming growth factor, beta receptor III). Replication studies verified the significant findings by GWAS. We also detected significant associations with hip fracture for
ADAMTS18 SNPs in the Chinese HF sample. Meta-analyses supported the significant associations of
ADAMTS18 and
TGFBR3 with BMD (p values: 2.56 × 10
−5 to 2.13 × 10
−8; total sample size: n = 5925 to 9828). Electrophoretic mobility shift assay suggested that the minor allele of one significant ADAMTS18 SNP might promote binding of the TEL2 factor, which may repress
ADAMTS18 expression. The data from NCBI GEO expression profiles also showed that
ADAMTS18 and
TGFBR3 genes were differentially expressed in subjects with normal skeletal fracture versus subjects with nonunion skeletal fracture. Overall, the evidence supports that
ADAMTS18 and
TGFBR3 might underlie BMD determination in the major human ethnic groups. |
|---|---|
| AbstractList | To identify and validate genes associated with bone mineral density (BMD), which is a prominent osteoporosis risk factor, we tested 379,319 SNPs in 1000 unrelated white U.S. subjects for associations with BMD. For replication, we genotyped the most significant SNPs in 593 white U.S. families (1972 subjects), a Chinese hip fracture (HF) sample (350 cases, 350 controls), a Chinese BMD sample (2955 subjects), and a Tobago cohort of African ancestry (908 males). Publicly available Framingham genome-wide association study (GWAS) data (2953 whites) were also used for in silico replication. The GWAS detected two BMD candidate genes, ADAMTS18 (ADAM metallopeptidase with thrombospondin type 1 motif, 18) and TGFBR3 (transforming growth factor, beta receptor III). Replication studies verified the significant findings by GWAS. We also detected significant associations with hip fracture for ADAMTS18 SNPs in the Chinese HF sample. Meta-analyses supported the significant associations of ADAMTS18 and TGFBR3 with BMD (p values: 2.56 x 10 super(-5) to 2.13 x 10 super(-8); total sample size: n = 5925 to 9828). Electrophoretic mobility shift assay suggested that the minor allele of one significant ADAMTS18 SNP might promote binding of the TEL2 factor, which may repress ADAMTS18 expression. The data from NCBI GEO expression profiles also showed that ADAMTS18 and TGFBR3 genes were differentially expressed in subjects with normal skeletal fracture versus subjects with nonunion skeletal fracture. Overall, the evidence supports that ADAMTS18 and TGFBR3 might underlie BMD determination in the major human ethnic groups. To identify and validate genes associated with bone mineral density (BMD), which is a prominent osteoporosis risk factor, we tested 379,319 SNPs in 1000 unrelated white U.S. subjects for associations with BMD. For replication, we genotyped the most significant SNPs in 593 white U.S. families (1972 subjects), a Chinese hip fracture (HF) sample (350 cases, 350 controls), a Chinese BMD sample (2955 subjects), and a Tobago cohort of African ancestry (908 males). Publicly available Framingham genome-wide association study (GWAS) data (2953 whites) were also used for in silico replication. The GWAS detected two BMD candidate genes, ADAMTS18 (ADAM metallopeptidase with thrombospondin type 1 motif, 18) and TGFBR3 (transforming growth factor, beta receptor III). Replication studies verified the significant findings by GWAS. We also detected significant associations with hip fracture for ADAMTS18 SNPs in the Chinese HF sample. Meta-analyses supported the significant associations of ADAMTS18 and TGFBR3 with BMD (p values: 2.56 x 10(-5) to 2.13 x 10(-8); total sample size: n = 5925 to 9828). Electrophoretic mobility shift assay suggested that the minor allele of one significant ADAMTS18 SNP might promote binding of the TEL2 factor, which may repress ADAMTS18 expression. The data from NCBI GEO expression profiles also showed that ADAMTS18 and TGFBR3 genes were differentially expressed in subjects with normal skeletal fracture versus subjects with nonunion skeletal fracture. Overall, the evidence supports that ADAMTS18 and TGFBR3 might underlie BMD determination in the major human ethnic groups. To identify and validate genes associated with bone mineral density (BMD), which is a prominent osteoporosis risk factor, we tested 379,319 SNPs in 1000 unrelated white U.S. subjects for associations with BMD. For replication, we genotyped the most significant SNPs in 593 white U.S. families (1972 subjects), a Chinese hip fracture (HF) sample (350 cases, 350 controls), a Chinese BMD sample (2955 subjects), and a Tobago cohort of African ancestry (908 males). Publicly available Framingham genome-wide association study (GWAS) data (2953 whites) were also used for in silico replication. The GWAS detected two BMD candidate genes, ADAMTS18 (ADAM metallopeptidase with thrombospondin type 1 motif, 18) and TGFBR3 (transforming growth factor, beta receptor III). Replication studies verified the significant findings by GWAS. We also detected significant associations with hip fracture for ADAMTS18 SNPs in the Chinese HF sample. Meta-analyses supported the significant associations of ADAMTS18 and TGFBR3 with BMD (p values: 2.56 × 10 −5 to 2.13 × 10 −8 ; total sample size: n = 5925 to 9828). Electrophoretic mobility shift assay suggested that the minor allele of one significant ADAMTS18 SNP might promote binding of the TEL2 factor, which may repress ADAMTS18 expression. The data from NCBI GEO expression profiles also showed that ADAMTS18 and TGFBR3 genes were differentially expressed in subjects with normal skeletal fracture versus subjects with nonunion skeletal fracture. Overall, the evidence supports that ADAMTS18 and TGFBR3 might underlie BMD determination in the major human ethnic groups. To identify and validate genes associated with bone mineral density (BMD), which is a prominent osteoporosis risk factor, we tested 379,319 SNPs in 1000 unrelated white U.S. subjects for associations with BMD. For replication, we genotyped the most significant SNPs in 593 white U.S. families (1972 subjects), a Chinese hip fracture (HF) sample (350 cases, 350 controls), a Chinese BMD sample (2955 subjects), and a Tobago cohort of African ancestry (908 males). Publicly available Framingham genome-wide association study (GWAS) data (2953 whites) were also used for in silico replication. The GWAS detected two BMD candidate genes, ADAMTS18 (ADAM metallopeptidase with thrombospondin type 1 motif, 18) and TGFBR3 (transforming growth factor, beta receptor III). Replication studies verified the significant findings by GWAS. We also detected significant associations with hip fracture for ADAMTS18 SNPs in the Chinese HF sample. Meta-analyses supported the significant associations of ADAMTS18 and TGFBR3 with BMD (p values: 2.56 x 10... to 2.13 x 10...; total sample size: n = 5925 to 9828). Electrophoretic mobility shift assay suggested that the minor allele of one significant ADAMTS18 SNP might promote binding of the TEL2 factor, which may repress ADAMTS18 expression. The data from NCBI GEO expression profiles also showed that ADAMTS18 and TGFBR3 genes were differentially expressed in subjects with normal skeletal fracture versus subjects with nonunion skeletal fracture. Overall, the evidence supports that ADAMTS18 and TGFBR3 might underlie BMD determination in the major human ethnic groups. (ProQuest: ... denotes formulae/symbols omitted.) To identify and validate genes associated with bone mineral density (BMD), which is a prominent osteoporosis risk factor, we tested 379,319 SNPs in 1000 unrelated white U.S. subjects for associations with BMD. For replication, we genotyped the most significant SNPs in 593 white U.S. families (1972 subjects), a Chinese hip fracture (HF) sample (350 cases, 350 controls), a Chinese BMD sample (2955 subjects), and a Tobago cohort of African ancestry (908 males). Publicly available Framingham genome-wide association study (GWAS) data (2953 whites) were also used for in silico replication. The GWAS detected two BMD candidate genes, ADAMTS18 (ADAM metallopeptidase with thrombospondin type 1 motif, 18) and TGFBR3 (transforming growth factor, beta receptor III). Replication studies verified the significant findings by GWAS. We also detected significant associations with hip fracture for ADAMTS18 SNPs in the Chinese HF sample. Meta-analyses supported the significant associations of ADAMTS18 and TGFBR3 with BMD (p values: 2.56 × 10 −5 to 2.13 × 10 −8; total sample size: n = 5925 to 9828). Electrophoretic mobility shift assay suggested that the minor allele of one significant ADAMTS18 SNP might promote binding of the TEL2 factor, which may repress ADAMTS18 expression. The data from NCBI GEO expression profiles also showed that ADAMTS18 and TGFBR3 genes were differentially expressed in subjects with normal skeletal fracture versus subjects with nonunion skeletal fracture. Overall, the evidence supports that ADAMTS18 and TGFBR3 might underlie BMD determination in the major human ethnic groups. |
| Author | Lundberg, Y. Wang Guo, Yan Wheeler, Victor W. Liu, Yao-Zhong Lei, Shu-Feng Chen, Xiang-Ding Yan, Han Pei, Yu-Fang Pan, Feng Levy, Shawn Papasian, Christopher J. Deng, Hong-Wen Guo, Yan-Fang Zhu, Xue-Zen Xiong, Dong-Hai Tan, Li-Jun Yerges, Laura M. Zmuda, Joseph M. Yang, Tie-Lin Recker, Robert R. Tang, Zi-Hui Liu, Xiao-Gang Xiao, Peng Patrick, Alan L. Bunker, ClareAnn H. Liu, Yong-Jun Wang, Liang Zhang, Yin-Pin Sha, Bao-Yong |
| AuthorAffiliation | 6 Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261, USA 5 Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA 8 Vanderbilt Microarray Shared Resource, Vanderbilt University, Nashville, TN 37232, USA 3 Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, People's Republic of China 7 Tobago Health Studies Office, Scarborough, Tobago, Trinidad and Tobago 2 The Key Laboratory of Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, People's Republic of China 4 Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA 1 Departments of Orthopedic Surgery and Basic Medical Sciences, University of Missouri-Kansas City, Kansas City, MO 64108, USA 9 Genetics Department, Boys Town National Research Hospital, Omaha, NE, 68131, USA |
| AuthorAffiliation_xml | – name: 3 Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, People's Republic of China – name: 4 Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA – name: 6 Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261, USA – name: 7 Tobago Health Studies Office, Scarborough, Tobago, Trinidad and Tobago – name: 2 The Key Laboratory of Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, People's Republic of China – name: 5 Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA – name: 9 Genetics Department, Boys Town National Research Hospital, Omaha, NE, 68131, USA – name: 8 Vanderbilt Microarray Shared Resource, Vanderbilt University, Nashville, TN 37232, USA – name: 1 Departments of Orthopedic Surgery and Basic Medical Sciences, University of Missouri-Kansas City, Kansas City, MO 64108, USA |
| Author_xml | – sequence: 1 givenname: Dong-Hai surname: Xiong fullname: Xiong, Dong-Hai organization: Departments of Orthopedic Surgery and Basic Medical Sciences, University of Missouri-Kansas City, Kansas City, MO 64108, USA – sequence: 2 givenname: Xiao-Gang surname: Liu fullname: Liu, Xiao-Gang organization: The Key Laboratory of Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, People's Republic of China – sequence: 3 givenname: Yan-Fang surname: Guo fullname: Guo, Yan-Fang organization: The Key Laboratory of Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, People's Republic of China – sequence: 4 givenname: Li-Jun surname: Tan fullname: Tan, Li-Jun organization: Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, People's Republic of China – sequence: 5 givenname: Liang surname: Wang fullname: Wang, Liang organization: The Key Laboratory of Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, People's Republic of China – sequence: 6 givenname: Bao-Yong surname: Sha fullname: Sha, Bao-Yong organization: Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, People's Republic of China – sequence: 7 givenname: Zi-Hui surname: Tang fullname: Tang, Zi-Hui organization: Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, People's Republic of China – sequence: 8 givenname: Feng surname: Pan fullname: Pan, Feng organization: The Key Laboratory of Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, People's Republic of China – sequence: 9 givenname: Tie-Lin surname: Yang fullname: Yang, Tie-Lin organization: The Key Laboratory of Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, People's Republic of China – sequence: 10 givenname: Xiang-Ding surname: Chen fullname: Chen, Xiang-Ding organization: Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, People's Republic of China – sequence: 11 givenname: Shu-Feng surname: Lei fullname: Lei, Shu-Feng organization: Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, People's Republic of China – sequence: 12 givenname: Laura M. surname: Yerges fullname: Yerges, Laura M. organization: Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA – sequence: 13 givenname: Xue-Zen surname: Zhu fullname: Zhu, Xue-Zen organization: The Key Laboratory of Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, People's Republic of China – sequence: 14 givenname: Victor W. surname: Wheeler fullname: Wheeler, Victor W. organization: Tobago Health Studies Office, Scarborough, Tobago, Trinidad and Tobago – sequence: 15 givenname: Alan L. surname: Patrick fullname: Patrick, Alan L. organization: Tobago Health Studies Office, Scarborough, Tobago, Trinidad and Tobago – sequence: 16 givenname: ClareAnn H. surname: Bunker fullname: Bunker, ClareAnn H. organization: Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA – sequence: 17 givenname: Yan surname: Guo fullname: Guo, Yan organization: The Key Laboratory of Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, People's Republic of China – sequence: 18 givenname: Han surname: Yan fullname: Yan, Han organization: The Key Laboratory of Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, People's Republic of China – sequence: 19 givenname: Yu-Fang surname: Pei fullname: Pei, Yu-Fang organization: The Key Laboratory of Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, People's Republic of China – sequence: 20 givenname: Yin-Pin surname: Zhang fullname: Zhang, Yin-Pin organization: Departments of Orthopedic Surgery and Basic Medical Sciences, University of Missouri-Kansas City, Kansas City, MO 64108, USA – sequence: 21 givenname: Shawn surname: Levy fullname: Levy, Shawn organization: Vanderbilt Microarray Shared Resource, Vanderbilt University, Nashville, TN 37232, USA – sequence: 22 givenname: Christopher J. surname: Papasian fullname: Papasian, Christopher J. organization: Departments of Orthopedic Surgery and Basic Medical Sciences, University of Missouri-Kansas City, Kansas City, MO 64108, USA – sequence: 23 givenname: Peng surname: Xiao fullname: Xiao, Peng organization: Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA – sequence: 24 givenname: Y. Wang surname: Lundberg fullname: Lundberg, Y. Wang organization: Genetics Department, Boys Town National Research Hospital, Omaha, NE, 68131, USA – sequence: 25 givenname: Robert R. surname: Recker fullname: Recker, Robert R. organization: Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA – sequence: 26 givenname: Yao-Zhong surname: Liu fullname: Liu, Yao-Zhong organization: Departments of Orthopedic Surgery and Basic Medical Sciences, University of Missouri-Kansas City, Kansas City, MO 64108, USA – sequence: 27 givenname: Yong-Jun surname: Liu fullname: Liu, Yong-Jun organization: Departments of Orthopedic Surgery and Basic Medical Sciences, University of Missouri-Kansas City, Kansas City, MO 64108, USA – sequence: 28 givenname: Joseph M. surname: Zmuda fullname: Zmuda, Joseph M. organization: Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA – sequence: 29 givenname: Hong-Wen surname: Deng fullname: Deng, Hong-Wen email: dengh@umkc.edu organization: Departments of Orthopedic Surgery and Basic Medical Sciences, University of Missouri-Kansas City, Kansas City, MO 64108, USA |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21261994$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/19249006$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1093/nar/gkl236 10.7326/0003-4819-145-4-200608150-00005 10.1359/jbmr.051002 10.1074/jbc.M704883200 10.1038/ng1847 10.1126/science.1083195 10.1371/journal.pone.0003160 10.1016/S8756-3282(98)00080-5 10.1016/j.ajhg.2008.10.006 10.1111/j.1420-9101.2005.00917.x 10.1074/jbc.M010070200 10.1182/blood.V95.11.3341.011k44_3341_3348 10.1359/jbmr.2000.15.4.710 10.1001/jama.292.17.2105 10.1038/ng.120 10.1038/sj.mp.4001983 10.1371/journal.pbio.0000069 10.1186/1471-2350-8-S1-S1 10.1002/jbmr.5650070511 10.1093/hmg/ddn072 10.1086/344696 10.1677/joe.0.1770147 10.1159/000057986 10.1007/s00198-007-0450-9 10.1016/j.bone.2005.11.024 10.1359/JBMR.050906 10.1128/MCB.23.12.4371-4385.2003 10.1359/jbmr.1997.12.1.24 10.1016/S0002-9343(05)80041-5 10.1371/journal.pmed.0030090 10.1093/bioinformatics/bth457 10.1001/jama.299.11.1277 10.1159/000089553 10.1007/s00431-003-1343-3 |
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| References | Lange, DeMeo, Laird (bib25) 2002; 71 Lencz, Morgan, Athanasiou, Dain, Reed, Kane, Kucherlapati, Malhotra (bib15) 2007; 12 Ray, Chan, Thamer, Melton (bib2) 1997; 12 Cupples, Arruda, Benjamin, D'Agostino, Demissie, DeStefano, Dupuis, Falls, Fox, Gottlieb (bib19) 2007; 8 Hannan, Felson, Dawson-Hughes, Tucker, Cupples, Wilson, Kiel (bib21) 2000; 15 Miljkovic-Gacic, Ferrell, Patrick, Kammerer, Bunker (bib24) 2005; 60 Stenvers, Tursky, Harder, Kountouri, Amatayakul-Chantler, Grail, Small, Weinberg, Sizeland, Zhu (bib34) 2003; 23 Price, Patterson, Plenge, Weinblatt, Shadick, Reich (bib16) 2006; 38 Horner, Kemp, Summers, Bord, Bishop, Kelsall, Coleman, Compston (bib31) 1998; 23 van Meurs, Trikalinos, Ralston, Balcells, Brandi, Brixen, Kiel, Langdahl, Lips, Ljunggren (bib7) 2008; 299 Ralston, Uitterlinden, Brandi, Balcells, Langdahl, Lips, Lorenc, Obermayer-Pietsch, Scollen, Bustamante (bib5) 2006; 3 Liu, Liu, Recker, Deng (bib10) 2003; 177 Reginster, Burlet (bib1) 2006; 38 Liu, Shen, Xiao, Xiong, Li, Recker, Deng (bib9) 2006; 21 Liu, Liu, Wang, Dina, Yan, Liu, Levy, Papasian, Drees, Hamilton (bib11) 2008; 17 Yang, Chen, Guo, Lei, Wang, Zhou, Pan, Chen, Zhang, Dong (bib13) 2008; 83 Cummings, Black (bib3) 1995; 98 Zaykin, Westfall, Young, Karnoub, Wagner, Ehm (bib14) 2002; 53 Whitlock (bib26) 2005; 18 Yuan, Chiou, Tseng, Liu, Liu, Lin, Wang, Yao, Chen, Hsu (bib18) 2006; 34 Styrkarsdottir, Cazier, Kong, Rolfsson, Larsen, Bjarnadottir, Johannsdottir, Sigurdardottir, Bagger, Christiansen (bib33) 2003; 1 Kirkbride, Townsend, Bruinsma, Barnett, Blobe (bib32) 2008; 283 Hill, Cauley, Sheu, Bunker, Patrick, Baker, Beckles, Wheeler, Zmuda (bib23) 2008; 19 Gu, Shin, Akbarali, Weiss, Boltax, Oettgen, Libermann (bib28) 2001; 276 Macdonald, McGuigan, Stewart, Black, Fraser, Ralston, Reid (bib4) 2006; 21 Liu, Wilson, Wang, Liu, Guo, Li, Yan, Deloukas, Soranzo, Chinnapen-Horsley (bib12) 2008; 3 Ioannidis, Ralston, Bennett, Brandi, Grinberg, Karassa, Langdahl, van Meurs, Mosekilde, Scollen (bib6) 2004; 292 Zeggini, Scott, Saxena, Voight, Marchini, Hu, de Bakker, Abecasis, Almgren, Andersen (bib27) 2008; 40 Potter, Buijs, Kreider, van Rompaey, Grosveld (bib29) 2000; 95 Uitterlinden, Ralston, Brandi, Carey, Grinberg, Langdahl, Lips, Lorenc, Obermayer-Pietsch, Reeve (bib8) 2006; 145 Chen, Kirkbride, How, Nelson, Mo, Frederick, Wang, Lefkowitz, Blobe (bib30) 2003; 301 Barrett, Fry, Maller, Daly (bib17) 2005; 21 Braun, Roth, McGinniss (bib22) 2003; 162 Hannan, Felson, Anderson (bib20) 1992; 7 Yuan (10.1016/j.ajhg.2009.01.025_bib18) 2006; 34 Zaykin (10.1016/j.ajhg.2009.01.025_bib14) 2002; 53 Zeggini (10.1016/j.ajhg.2009.01.025_bib27) 2008; 40 Liu (10.1016/j.ajhg.2009.01.025_bib10) 2003; 177 Reginster (10.1016/j.ajhg.2009.01.025_bib1) 2006; 38 Potter (10.1016/j.ajhg.2009.01.025_bib29) 2000; 95 Ralston (10.1016/j.ajhg.2009.01.025_bib5) 2006; 3 Kirkbride (10.1016/j.ajhg.2009.01.025_bib32) 2008; 283 Braun (10.1016/j.ajhg.2009.01.025_bib22) 2003; 162 Yang (10.1016/j.ajhg.2009.01.025_bib13) 2008; 83 Hill (10.1016/j.ajhg.2009.01.025_bib23) 2008; 19 Macdonald (10.1016/j.ajhg.2009.01.025_bib4) 2006; 21 Cupples (10.1016/j.ajhg.2009.01.025_bib19) 2007; 8 Hannan (10.1016/j.ajhg.2009.01.025_bib21) 2000; 15 Cummings (10.1016/j.ajhg.2009.01.025_bib3) 1995; 98 Barrett (10.1016/j.ajhg.2009.01.025_bib17) 2005; 21 Stenvers (10.1016/j.ajhg.2009.01.025_bib34) 2003; 23 Styrkarsdottir (10.1016/j.ajhg.2009.01.025_bib33) 2003; 1 Whitlock (10.1016/j.ajhg.2009.01.025_bib26) 2005; 18 Chen (10.1016/j.ajhg.2009.01.025_bib30) 2003; 301 Uitterlinden (10.1016/j.ajhg.2009.01.025_bib8) 2006; 145 Ioannidis (10.1016/j.ajhg.2009.01.025_bib6) 2004; 292 Lencz (10.1016/j.ajhg.2009.01.025_bib15) 2007; 12 van Meurs (10.1016/j.ajhg.2009.01.025_bib7) 2008; 299 Gu (10.1016/j.ajhg.2009.01.025_bib28) 2001; 276 Liu (10.1016/j.ajhg.2009.01.025_bib9) 2006; 21 Price (10.1016/j.ajhg.2009.01.025_bib16) 2006; 38 Liu (10.1016/j.ajhg.2009.01.025_bib11) 2008; 17 Ray (10.1016/j.ajhg.2009.01.025_bib2) 1997; 12 Miljkovic-Gacic (10.1016/j.ajhg.2009.01.025_bib24) 2005; 60 Liu (10.1016/j.ajhg.2009.01.025_bib12) 2008; 3 Hannan (10.1016/j.ajhg.2009.01.025_bib20) 1992; 7 Lange (10.1016/j.ajhg.2009.01.025_bib25) 2002; 71 Horner (10.1016/j.ajhg.2009.01.025_bib31) 1998; 23 17522711 - Mol Psychiatry. 2007 Jun;12(6):572-80 7709929 - Am J Med. 1995 Feb 27;98(2A):24S-28S 17874032 - Osteoporos Int. 2008 Feb;19(2):227-34 9701467 - Bone. 1998 Aug;23(2):95-102 18776929 - PLoS One. 2008;3(9):e3160 15523071 - JAMA. 2004 Nov 3;292(17):2105-14 16995806 - J Bone Miner Res. 2006 Oct;21(10):1511-35 10780863 - J Bone Miner Res. 2000 Apr;15(4):710-20 18372903 - Nat Genet. 2008 May;40(5):638-45 18992858 - Am J Hum Genet. 2008 Dec;83(6):663-74 12037407 - Hum Hered. 2002;53(2):79-91 16908916 - Ann Intern Med. 2006 Aug 15;145(4):255-64 12958365 - Science. 2003 Sep 5;301(5638):1394-7 16475872 - PLoS Med. 2006 Apr;3(4):e90 18325910 - Hum Mol Genet. 2008 Jun 15;17(12):1803-13 12773577 - Mol Cell Biol. 2003 Jun;23(12):4371-85 16355284 - J Bone Miner Res. 2006 Jan;21(1):151-62 12740006 - J Endocrinol. 2003 May;177(2):147-96 18349089 - JAMA. 2008 Mar 19;299(11):1277-90 16135132 - J Evol Biol. 2005 Sep;18(5):1368-73 14691541 - PLoS Biol. 2003 Dec;1(3):E69 16282694 - Hum Hered. 2005;60(3):129-33 14574571 - Eur J Pediatr. 2003 Dec;162 Suppl 1:S13-6 16845089 - Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W635-41 1615761 - J Bone Miner Res. 1992 May;7(5):547-53 12454799 - Am J Hum Genet. 2002 Dec;71(6):1330-41 16455317 - Bone. 2006 Feb;38(2 Suppl 1):S4-9 16862161 - Nat Genet. 2006 Aug;38(8):904-9 17903291 - BMC Med Genet. 2007;8 Suppl 1:S1 11108721 - J Biol Chem. 2001 Mar 23;276(12):9421-36 15297300 - Bioinformatics. 2005 Jan 15;21(2):263-5 9240722 - J Bone Miner Res. 1997 Jan;12(1):24-35 18184661 - J Biol Chem. 2008 Mar 21;283(12):7628-37 10828014 - Blood. 2000 Jun 1;95(11):3341-8 |
| References_xml | – volume: 53 start-page: 79 year: 2002 end-page: 91 ident: bib14 article-title: Testing association of statistically inferred haplotypes with discrete and continuous traits in samples of unrelated individuals publication-title: Hum. Hered. – volume: 162 start-page: S13 year: 2003 end-page: S16 ident: bib22 article-title: Technology challenges in screening single gene disorders publication-title: Eur. J. Pediatr. – volume: 19 start-page: 227 year: 2008 end-page: 234 ident: bib23 article-title: Correlates of bone mineral density in men of African ancestry: the Tobago bone health study publication-title: Osteoporos. Int. – volume: 38 start-page: 904 year: 2006 end-page: 909 ident: bib16 article-title: Principal components analysis corrects for stratification in genome-wide association studies publication-title: Nat. Genet. – volume: 3 start-page: e3160 year: 2008 ident: bib12 article-title: Identification of PLCL1 gene for hip bone size variation in females in a genome-wide association study publication-title: PLoS. ONE – volume: 292 start-page: 2105 year: 2004 end-page: 2114 ident: bib6 article-title: Differential genetic effects of ESR1 gene polymorphisms on osteoporosis outcomes publication-title: JAMA – volume: 21 start-page: 151 year: 2006 end-page: 162 ident: bib4 article-title: Large-scale population-based study shows no evidence of association between common polymorphism of the VDR gene and BMD in British women publication-title: J. Bone Miner. Res. – volume: 276 start-page: 9421 year: 2001 end-page: 9436 ident: bib28 article-title: Tel-2 is a novel transcriptional repressor related to the Ets factor Tel/ETV-6 publication-title: J. Biol. Chem. – volume: 34 start-page: W635 year: 2006 end-page: W641 ident: bib18 article-title: FASTSNP: an always up-to-date and extendable service for SNP function analysis and prioritization publication-title: Nucleic Acids Res. – volume: 95 start-page: 3341 year: 2000 end-page: 3348 ident: bib29 article-title: Identification and characterization of a new human ETS-family transcription factor, TEL2, that is expressed in hematopoietic tissues and can associate with TEL1/ETV6 publication-title: Blood – volume: 17 start-page: 1803 year: 2008 end-page: 1813 ident: bib11 article-title: Genome-wide association scans identified CTNNBL1 as a novel gene for obesity publication-title: Hum. Mol. Genet. – volume: 7 start-page: 547 year: 1992 end-page: 553 ident: bib20 article-title: Bone mineral density in elderly men and women: results from the Framingham osteoporosis study publication-title: J. Bone Miner. Res. – volume: 23 start-page: 95 year: 1998 end-page: 102 ident: bib31 article-title: Expression and distribution of transforming growth factor-beta isoforms and their signaling receptors in growing human bone publication-title: Bone – volume: 1 start-page: E69 year: 2003 ident: bib33 article-title: Linkage of osteoporosis to chromosome 20p12 and association to BMP2 publication-title: PLoS Biol. – volume: 8 start-page: S1 year: 2007 ident: bib19 article-title: The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports publication-title: BMC Med. Genet. – volume: 145 start-page: 255 year: 2006 end-page: 264 ident: bib8 article-title: The association between common vitamin D receptor gene variations and osteoporosis: a participant-level meta-analysis publication-title: Ann. Intern. Med. – volume: 83 start-page: 663 year: 2008 end-page: 674 ident: bib13 article-title: Genome-wide copy-number-variation study identified a susceptibility gene, UGT2B17, for osteoporosis publication-title: Am. J. Hum. Genet. – volume: 21 start-page: 263 year: 2005 end-page: 265 ident: bib17 article-title: Haploview: analysis and visualization of LD and haplotype maps publication-title: Bioinformatics – volume: 40 start-page: 638 year: 2008 end-page: 645 ident: bib27 article-title: Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes publication-title: Nat. Genet. – volume: 283 start-page: 7628 year: 2008 end-page: 7637 ident: bib32 article-title: Bone morphogenetic proteins signal through the transforming growth factor-beta type III receptor publication-title: J. Biol. Chem. – volume: 12 start-page: 572 year: 2007 end-page: 580 ident: bib15 article-title: Converging evidence for a pseudoautosomal cytokine receptor gene locus in schizophrenia publication-title: Mol. Psychiatry – volume: 38 start-page: S4 year: 2006 end-page: S9 ident: bib1 article-title: Osteoporosis: a still increasing prevalence publication-title: Bone – volume: 3 start-page: e90 year: 2006 ident: bib5 article-title: Large-scale evidence for the effect of the COLIA1 Sp1 polymorphism on osteoporosis outcomes: the GENOMOS study publication-title: PLoS Med. – volume: 71 start-page: 1330 year: 2002 end-page: 1341 ident: bib25 article-title: Power and design considerations for a general class of family-based association tests: quantitative traits publication-title: Am. J. Hum. Genet. – volume: 23 start-page: 4371 year: 2003 end-page: 4385 ident: bib34 article-title: Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos publication-title: Mol. Cell. Biol. – volume: 177 start-page: 147 year: 2003 end-page: 196 ident: bib10 article-title: Molecular studies of identification of genes for osteoporosis: the 2002 update publication-title: J. Endocrinol. – volume: 98 start-page: 24S year: 1995 end-page: 28S ident: bib3 article-title: Bone mass measurements and risk of fracture in Caucasian women: a review of findings from prospective studies publication-title: Am. J. Med. – volume: 299 start-page: 1277 year: 2008 end-page: 1290 ident: bib7 article-title: Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis publication-title: JAMA – volume: 18 start-page: 1368 year: 2005 end-page: 1373 ident: bib26 article-title: Combining probability from independent tests: the weighted Z-method is superior to Fisher's approach publication-title: J. Evol. Biol. – volume: 301 start-page: 1394 year: 2003 end-page: 1397 ident: bib30 article-title: Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling publication-title: Science – volume: 15 start-page: 710 year: 2000 end-page: 720 ident: bib21 article-title: Risk factors for longitudinal bone loss in elderly men and women: the Framingham Osteoporosis Study publication-title: J. Bone Miner. Res. – volume: 21 start-page: 1511 year: 2006 end-page: 1535 ident: bib9 article-title: Molecular genetic studies of gene identification for osteoporosis: a 2004 update publication-title: J. Bone Miner. Res. – volume: 60 start-page: 129 year: 2005 end-page: 133 ident: bib24 article-title: Estimates of African, European and Native American ancestry in Afro-Caribbean men on the island of Tobago publication-title: Hum. Hered. – volume: 12 start-page: 24 year: 1997 end-page: 35 ident: bib2 article-title: Medical expenditures for the treatment of osteoporotic fractures in the United States in 1995: report from the National Osteoporosis Foundation publication-title: J. Bone Miner. Res. – volume: 34 start-page: W635 year: 2006 ident: 10.1016/j.ajhg.2009.01.025_bib18 article-title: FASTSNP: an always up-to-date and extendable service for SNP function analysis and prioritization publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkl236 – volume: 145 start-page: 255 year: 2006 ident: 10.1016/j.ajhg.2009.01.025_bib8 article-title: The association between common vitamin D receptor gene variations and osteoporosis: a participant-level meta-analysis publication-title: Ann. Intern. Med. doi: 10.7326/0003-4819-145-4-200608150-00005 – volume: 21 start-page: 1511 year: 2006 ident: 10.1016/j.ajhg.2009.01.025_bib9 article-title: Molecular genetic studies of gene identification for osteoporosis: a 2004 update publication-title: J. Bone Miner. Res. doi: 10.1359/jbmr.051002 – volume: 283 start-page: 7628 year: 2008 ident: 10.1016/j.ajhg.2009.01.025_bib32 article-title: Bone morphogenetic proteins signal through the transforming growth factor-beta type III receptor publication-title: J. Biol. Chem. doi: 10.1074/jbc.M704883200 – volume: 38 start-page: 904 year: 2006 ident: 10.1016/j.ajhg.2009.01.025_bib16 article-title: Principal components analysis corrects for stratification in genome-wide association studies publication-title: Nat. Genet. doi: 10.1038/ng1847 – volume: 301 start-page: 1394 year: 2003 ident: 10.1016/j.ajhg.2009.01.025_bib30 article-title: Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling publication-title: Science doi: 10.1126/science.1083195 – volume: 3 start-page: e3160 year: 2008 ident: 10.1016/j.ajhg.2009.01.025_bib12 article-title: Identification of PLCL1 gene for hip bone size variation in females in a genome-wide association study publication-title: PLoS. ONE doi: 10.1371/journal.pone.0003160 – volume: 23 start-page: 95 year: 1998 ident: 10.1016/j.ajhg.2009.01.025_bib31 article-title: Expression and distribution of transforming growth factor-beta isoforms and their signaling receptors in growing human bone publication-title: Bone doi: 10.1016/S8756-3282(98)00080-5 – volume: 83 start-page: 663 year: 2008 ident: 10.1016/j.ajhg.2009.01.025_bib13 article-title: Genome-wide copy-number-variation study identified a susceptibility gene, UGT2B17, for osteoporosis publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2008.10.006 – volume: 18 start-page: 1368 year: 2005 ident: 10.1016/j.ajhg.2009.01.025_bib26 article-title: Combining probability from independent tests: the weighted Z-method is superior to Fisher's approach publication-title: J. Evol. Biol. doi: 10.1111/j.1420-9101.2005.00917.x – volume: 276 start-page: 9421 year: 2001 ident: 10.1016/j.ajhg.2009.01.025_bib28 article-title: Tel-2 is a novel transcriptional repressor related to the Ets factor Tel/ETV-6 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M010070200 – volume: 95 start-page: 3341 year: 2000 ident: 10.1016/j.ajhg.2009.01.025_bib29 article-title: Identification and characterization of a new human ETS-family transcription factor, TEL2, that is expressed in hematopoietic tissues and can associate with TEL1/ETV6 publication-title: Blood doi: 10.1182/blood.V95.11.3341.011k44_3341_3348 – volume: 15 start-page: 710 year: 2000 ident: 10.1016/j.ajhg.2009.01.025_bib21 article-title: Risk factors for longitudinal bone loss in elderly men and women: the Framingham Osteoporosis Study publication-title: J. Bone Miner. Res. doi: 10.1359/jbmr.2000.15.4.710 – volume: 292 start-page: 2105 year: 2004 ident: 10.1016/j.ajhg.2009.01.025_bib6 article-title: Differential genetic effects of ESR1 gene polymorphisms on osteoporosis outcomes publication-title: JAMA doi: 10.1001/jama.292.17.2105 – volume: 40 start-page: 638 year: 2008 ident: 10.1016/j.ajhg.2009.01.025_bib27 article-title: Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes publication-title: Nat. Genet. doi: 10.1038/ng.120 – volume: 12 start-page: 572 year: 2007 ident: 10.1016/j.ajhg.2009.01.025_bib15 article-title: Converging evidence for a pseudoautosomal cytokine receptor gene locus in schizophrenia publication-title: Mol. Psychiatry doi: 10.1038/sj.mp.4001983 – volume: 1 start-page: E69 year: 2003 ident: 10.1016/j.ajhg.2009.01.025_bib33 article-title: Linkage of osteoporosis to chromosome 20p12 and association to BMP2 publication-title: PLoS Biol. doi: 10.1371/journal.pbio.0000069 – volume: 8 start-page: S1 issue: Suppl 1 year: 2007 ident: 10.1016/j.ajhg.2009.01.025_bib19 article-title: The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports publication-title: BMC Med. Genet. doi: 10.1186/1471-2350-8-S1-S1 – volume: 7 start-page: 547 year: 1992 ident: 10.1016/j.ajhg.2009.01.025_bib20 article-title: Bone mineral density in elderly men and women: results from the Framingham osteoporosis study publication-title: J. Bone Miner. Res. doi: 10.1002/jbmr.5650070511 – volume: 17 start-page: 1803 year: 2008 ident: 10.1016/j.ajhg.2009.01.025_bib11 article-title: Genome-wide association scans identified CTNNBL1 as a novel gene for obesity publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddn072 – volume: 71 start-page: 1330 year: 2002 ident: 10.1016/j.ajhg.2009.01.025_bib25 article-title: Power and design considerations for a general class of family-based association tests: quantitative traits publication-title: Am. J. Hum. Genet. doi: 10.1086/344696 – volume: 177 start-page: 147 year: 2003 ident: 10.1016/j.ajhg.2009.01.025_bib10 article-title: Molecular studies of identification of genes for osteoporosis: the 2002 update publication-title: J. Endocrinol. doi: 10.1677/joe.0.1770147 – volume: 53 start-page: 79 year: 2002 ident: 10.1016/j.ajhg.2009.01.025_bib14 article-title: Testing association of statistically inferred haplotypes with discrete and continuous traits in samples of unrelated individuals publication-title: Hum. Hered. doi: 10.1159/000057986 – volume: 19 start-page: 227 year: 2008 ident: 10.1016/j.ajhg.2009.01.025_bib23 article-title: Correlates of bone mineral density in men of African ancestry: the Tobago bone health study publication-title: Osteoporos. Int. doi: 10.1007/s00198-007-0450-9 – volume: 38 start-page: S4 year: 2006 ident: 10.1016/j.ajhg.2009.01.025_bib1 article-title: Osteoporosis: a still increasing prevalence publication-title: Bone doi: 10.1016/j.bone.2005.11.024 – volume: 21 start-page: 151 year: 2006 ident: 10.1016/j.ajhg.2009.01.025_bib4 article-title: Large-scale population-based study shows no evidence of association between common polymorphism of the VDR gene and BMD in British women publication-title: J. Bone Miner. Res. doi: 10.1359/JBMR.050906 – volume: 23 start-page: 4371 year: 2003 ident: 10.1016/j.ajhg.2009.01.025_bib34 article-title: Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.23.12.4371-4385.2003 – volume: 12 start-page: 24 year: 1997 ident: 10.1016/j.ajhg.2009.01.025_bib2 article-title: Medical expenditures for the treatment of osteoporotic fractures in the United States in 1995: report from the National Osteoporosis Foundation publication-title: J. Bone Miner. Res. doi: 10.1359/jbmr.1997.12.1.24 – volume: 98 start-page: 24S year: 1995 ident: 10.1016/j.ajhg.2009.01.025_bib3 article-title: Bone mass measurements and risk of fracture in Caucasian women: a review of findings from prospective studies publication-title: Am. J. Med. doi: 10.1016/S0002-9343(05)80041-5 – volume: 3 start-page: e90 year: 2006 ident: 10.1016/j.ajhg.2009.01.025_bib5 article-title: Large-scale evidence for the effect of the COLIA1 Sp1 polymorphism on osteoporosis outcomes: the GENOMOS study publication-title: PLoS Med. doi: 10.1371/journal.pmed.0030090 – volume: 21 start-page: 263 year: 2005 ident: 10.1016/j.ajhg.2009.01.025_bib17 article-title: Haploview: analysis and visualization of LD and haplotype maps publication-title: Bioinformatics doi: 10.1093/bioinformatics/bth457 – volume: 299 start-page: 1277 year: 2008 ident: 10.1016/j.ajhg.2009.01.025_bib7 article-title: Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis publication-title: JAMA doi: 10.1001/jama.299.11.1277 – volume: 60 start-page: 129 year: 2005 ident: 10.1016/j.ajhg.2009.01.025_bib24 article-title: Estimates of African, European and Native American ancestry in Afro-Caribbean men on the island of Tobago publication-title: Hum. Hered. doi: 10.1159/000089553 – volume: 162 start-page: S13 issue: Suppl 1 year: 2003 ident: 10.1016/j.ajhg.2009.01.025_bib22 article-title: Technology challenges in screening single gene disorders publication-title: Eur. J. Pediatr. doi: 10.1007/s00431-003-1343-3 – reference: 16355284 - J Bone Miner Res. 2006 Jan;21(1):151-62 – reference: 10828014 - Blood. 2000 Jun 1;95(11):3341-8 – reference: 16845089 - Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W635-41 – reference: 18184661 - J Biol Chem. 2008 Mar 21;283(12):7628-37 – reference: 17874032 - Osteoporos Int. 2008 Feb;19(2):227-34 – reference: 15523071 - JAMA. 2004 Nov 3;292(17):2105-14 – reference: 18776929 - PLoS One. 2008;3(9):e3160 – reference: 18325910 - Hum Mol Genet. 2008 Jun 15;17(12):1803-13 – reference: 16135132 - J Evol Biol. 2005 Sep;18(5):1368-73 – reference: 16282694 - Hum Hered. 2005;60(3):129-33 – reference: 17522711 - Mol Psychiatry. 2007 Jun;12(6):572-80 – reference: 18372903 - Nat Genet. 2008 May;40(5):638-45 – reference: 12454799 - Am J Hum Genet. 2002 Dec;71(6):1330-41 – reference: 16908916 - Ann Intern Med. 2006 Aug 15;145(4):255-64 – reference: 12037407 - Hum Hered. 2002;53(2):79-91 – reference: 14691541 - PLoS Biol. 2003 Dec;1(3):E69 – reference: 1615761 - J Bone Miner Res. 1992 May;7(5):547-53 – reference: 16995806 - J Bone Miner Res. 2006 Oct;21(10):1511-35 – reference: 18349089 - JAMA. 2008 Mar 19;299(11):1277-90 – reference: 11108721 - J Biol Chem. 2001 Mar 23;276(12):9421-36 – reference: 16455317 - Bone. 2006 Feb;38(2 Suppl 1):S4-9 – reference: 17903291 - BMC Med Genet. 2007;8 Suppl 1:S1 – reference: 10780863 - J Bone Miner Res. 2000 Apr;15(4):710-20 – reference: 9701467 - Bone. 1998 Aug;23(2):95-102 – reference: 18992858 - Am J Hum Genet. 2008 Dec;83(6):663-74 – reference: 12740006 - J Endocrinol. 2003 May;177(2):147-96 – reference: 12773577 - Mol Cell Biol. 2003 Jun;23(12):4371-85 – reference: 14574571 - Eur J Pediatr. 2003 Dec;162 Suppl 1:S13-6 – reference: 16475872 - PLoS Med. 2006 Apr;3(4):e90 – reference: 9240722 - J Bone Miner Res. 1997 Jan;12(1):24-35 – reference: 16862161 - Nat Genet. 2006 Aug;38(8):904-9 – reference: 15297300 - Bioinformatics. 2005 Jan 15;21(2):263-5 – reference: 12958365 - Science. 2003 Sep 5;301(5638):1394-7 – reference: 7709929 - Am J Med. 1995 Feb 27;98(2A):24S-28S |
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| SubjectTerms | ADAM Proteins - genetics ADAMTS Proteins Adult African Continental Ancestry Group Aged Asian Continental Ancestry Group Biological and medical sciences Bone density Bone Density - genetics Databases, Genetic European Continental Ancestry Group Female Follow-Up Studies Fundamental and applied biological sciences. Psychology General aspects. Genetic counseling Genes Genetic Predisposition to Disease Genetic research Genetics of eukaryotes. Biological and molecular evolution Genome-Wide Association Study Genomics Hip Fractures - ethnology Hip Fractures - etiology Hip Fractures - genetics Humans Male Medical genetics Medical sciences Middle Aged Minority & ethnic groups Molecular and cellular biology Osteoporosis Osteoporosis - complications Osteoporosis - ethnology Osteoporosis - genetics Polymorphism, Single Nucleotide Proteoglycans - genetics Receptors, Transforming Growth Factor beta - genetics Risk factors Young Adult |
| Title | Genome-wide Association and Follow-Up Replication Studies Identified ADAMTS18 and TGFBR3 as Bone Mass Candidate Genes in Different Ethnic Groups |
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