Nanomaterial-Based Tumor Photothermal Immunotherapy

• Published in: International journal of nanomedicine Vol. 15; pp. 9159 - 9180
• Main Authors: Xu, Peng, Liang, Feng
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2020; Taylor & Francis Ltd; Dove; Dove Medical Press
• Subjects: Animals; Antigens; Apoptosis; Book publishing; Cancer; Cancer therapies; Carbon; Cell death; Chemotherapy; Cytokines; Cytokines - metabolism; Drug therapy; Fever; Graphene; Health aspects; Heat resistance; Humans; Hyperthermia; Hyperthermia, Induced - methods; Immune response; Immune system; immunogenic cell death; Immunotherapy; Immunotherapy - methods; Lasers; Medical research; Metastasis; Nanomaterials; Nanoparticles; Nanostructures - chemistry; Nanostructures - therapeutic use; Neoplasms - pathology; Neoplasms - therapy; Peptides; Phototherapy - methods; photothermal immunotherapy; photothermal therapy; Review; T cells; T-Lymphocytes - drug effects; T-Lymphocytes - immunology; tumor microenvironment; Tumor Microenvironment - drug effects; Tumors; United States; photothermal immunotherapy; nanomaterials; cell death mechanism of PTT; tumor microenvironment; immunogenic cell death
• ISSN: 1178-2013; 1176-9114; 1178-2013
• DOI: 10.2147/IJN.S249252

In recent years, photothermal therapy (PTT) particularly nanomaterial-based PTT is a promising therapeutic modality and technique for cancer tumor ablation. In addition to killing tumor cells directly through heat, PTT also can induce immunogenic cell death (ICD) to activate the whole-body anti-tumor immune response, including the redistribution and activation of immune effector cells, the expression and secretion of cytokines and the transformation of memory T lymphocytes. When used in combination with immunotherapy, the efficacy of nanomaterial-based PTT can be improved. This article summarized the mechanism of nanomaterial-based PTT against cancer and how nanomaterial-based PTT impacts the tumor microenvironment and induces an immune response. Moreover, we reviewed recent advances of nanomaterial-based photothermal immunotherapy and discussed challenges and future outlook.