Establishment and Application Evaluation of an Improved Obstructive Sleep Apnea Screening Questionnaire for Chinese Community: The CNCQ-OSA

• Published in: Nature and science of sleep Vol. 15; pp. 103 - 114
• Main Authors: Wang, Donghao, Ren, Yingying, Chen, Riken, Zeng, Xiangxia, Gan, Qiming, Zhuang, Zhiyang, Su, Xiaofen, Wu, Kang, Zhang, Sun, Tang, Yongkang, Li, Shiwei, Zhang, Haojie, Zhou, Yanyan, Zhang, Nuofu, Zhao, Dongxing
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2023; Taylor & Francis Ltd; Dove; Dove Medical Press
• Subjects: Age; Body mass index; Cardiovascular disease; Chronic illnesses; Comparative analysis; Diabetes; Gender; goal; Hypertension; nosas; Obesity; obstructive sleep apnea; Original Research; Oxygen saturation; Patients; Physicians; Population; Questionnaires; Regression analysis; screening; Sleep apnea; Sleep apnea syndromes; stop-bang; China; obstructive sleep apnea; GOAL; screening; NoSAS; STOP-Bang
• ISSN: 1179-1608; 1179-1608
• DOI: 10.2147/NSS.S396695

Obstructive sleep apnea (OSA) is a common sleep-disordered breathing disease. We aimed to establish an improved screening questionnaire without physical examinations for OSA named the CNCQ-OSA (Chinese community questionnaire for OSA). A total of 2585 participants who visited sleep medicine center and underwent overnight polysomnography were grouped into two independent cohorts: derivation (n = 2180) and validation (n = 405). The CNCQ-OSA was designed according to the baseline of patients in derivation cohort. We comprehensively analyzed the data to evaluate the predictive value of the CNCQ-OSA, compared to the GOAL questionnaire, STOP-Bang questionnaire (SBQ) and NoSAS questionnaire. The CNCQ-OSA included seven variables: loud snoring, BMI ≥ 25 kg/m , male gender, apnea, sleepiness, hypertension and age ≥30, with a total score ranging from 7 to 16.7 points (≥13.5 points indicating high risk of OSA, ≥14.5 points indicating extremely high risk). In the derivation and validation cohorts, the areas under the curve of the CNCQ-OSA were 0.761 and 0.767, respectively. In the validation cohort, the sensitivity and specificity of a CNCQ-OSA score ≥13.5 points for the apnea-hypopnea index (AHI) ≥5/h were 0.821 and 0.559, respectively (Youden index, 0.380), and the score ≥14.5 points were 0.494 and 0.887, respectively (Youden index, 0.375). The CNCQ-OSA had a better predictive value for AHI ≥ 5/h, AHI > 15/h and AHI > 30/h, with the highest Youden index, compared to the other questionnaires. The CNCQ-OSA can effectively identify the risk of OSA, which is appropriate for self-screening at home without physical examinations.