New Antidiabetic Compounds, Mangiferin and Its Glucoside

• Published in: Biological & pharmaceutical bulletin Vol. 21; no. 12; pp. 1389 - 1390
• Main Authors: ICHIKI, Hiroyuki, MIURA, Toshihiro, KUBO, Masayoshi, ISHIHARA, Eriko, KOMATSU, Yasuhiro, TANIGAWA, Keiichiro, OKADA, Minoru
• Format: Journal Article
• Language: English
• Published: Tokyo The Pharmaceutical Society of Japan 1998; Maruzen; Japan Science and Technology Agency
• Subjects: Animals; antidiabetic activity; Biological and medical sciences; Blood Glucose - drug effects; Diabetes Mellitus, Type 2 - drug therapy; Disease Models, Animal; General and cellular metabolism. Vitamins; Glucosides - chemistry; Glucosides - therapeutic use; Hyperinsulinism - drug therapy; Hypoglycemic Agents - chemistry; Hypoglycemic Agents - therapeutic use; KK-Ay mice; Male; mangiferin; mangiferin-7-O-β-glucoside; Medical sciences; Mice; Pharmacology. Drug treatments; Xanthenes - chemistry; Xanthenes - therapeutic use; Xanthones; Endocrinopathy; Monocotyledones; Treatment efficiency; Rodentia; Glucoside; Oral administration; Strain specificity; Non insulin dependent diabetes; Medicinal plant; Liliaceae; Vertebrata; Hypoglycemic agent; Mammalia; Mouse; Animal; Angiospermae; Plant origin; Genetics; Spermatophyta; Phytotherapy
• ISSN: 0918-6158; 1347-5215
• DOI: 10.1248/bpb.21.1389

Mangiferin (MF) and its glucosides (mangiferin-7-O-β-glucoside) (MG) isolated from Anemarrhena asphodeloides Bunge rhizome, were tested for their antidiabetic activity in KK-Ay mice, an animal model of non-insulin-dependent diabetes mellitus (NIDDM). MF and MG lowered the blood glucose level of KK-Ay mice after oral administration. However, no affect on the blood glucose level in normal mice was seen, indicating that MF and MG are useful in treating NIDDM. In addition, MF or MG improved hyperinsulinemia in KK-Ay mice. From these findings, it seems likely that MF and MG exert their its antidiabetic activity by increasing insulin sensitivity.