TETRONOTHIODIN, A NOVEL CHOLECYSTOKININ TYPE-B RECEPTOR ANTAGONIST PRODUCED BY Streptomyces sp

Cholecystokinin (CCK) is a hormonal regulator of pancreatic secretion as well as gallbladder contraction and gut motility. It has also been proposed as a neurotransmitter in central nervous system. In our screening program for new binding inhibitors of brain-type CCK (CCK-B) receptors from microorga...

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Published inJournal of antibiotics Vol. 45; no. 1; pp. 140 - 143
Main Authors OHTSUKA, TATSUO, KUDOH, TSUTOMU, SHIMMA, NOBUO, KOTAKI, HIROMICHI, NAKAYAMA, NOBORU, ITEZONO, YOSHIKO, FUJISAKI, NORIKO, WATANABE, JUNKO, YOKOSE, KAZUTERU, SETO, HARUO
Format Journal Article
LanguageEnglish
Published Japan JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 01.01.1992
Subjects
Animals
Brain - metabolism
Furans - chemistry
Furans - isolation & purification
Furans - pharmacology
Molecular Structure
Pancreas - metabolism
Rats
Receptors, Cholecystokinin - antagonists & inhibitors
Streptomyces
Streptomyces - metabolism
Thiophenes - chemistry
Thiophenes - isolation & purification
Thiophenes - pharmacology
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Summary:Cholecystokinin (CCK) is a hormonal regulator of pancreatic secretion as well as gallbladder contraction and gut motility. It has also been proposed as a neurotransmitter in central nervous system. In our screening program for new binding inhibitors of brain-type CCK (CCK-B) receptors from microorganisms, we discovered a novel CCK-B receptor antagonist, tetronothiodin (1) from the culture filtrate of Streptomyces sp. NR0489. In this communication, we describe the fermentation, isolation, structural elucidation and biological properties of 1.
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ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.45.140