Diabetic cardiomyopathy and its mechanisms: Role of oxidative stress and damage

• Published in: Journal of diabetes investigation Vol. 5; no. 6; pp. 623 - 634
• Main Authors: Liu, Quan, Wang, Shudong, Cai, Lu
• Format: Journal Article
• Language: English
• Published: Japan Blackwell Publishing Ltd 01.11.2014; John Wiley & Sons, Inc; BlackWell Publishing Ltd
• Subjects: Anti-oxidants; Apoptosis; Cardiomyocytes; Cardiomyopathy; Cardiovascular disease; Coronary vessels; Deoxyribonucleic acid; Diabetes; Diabetes mellitus; Diabetic cardiomyopathy; Disease prevention; DNA; Enzymes; Gene expression; Growth factors; Heart failure; Hyperglycemia; Hyperlipidemia; Hypertension; Kinases; Microvasculature; Myocardium; Oxidants; Oxidative stress; Pathogenesis; Physiology; Proteins; Review; Risk factors; Transduction; Vascular diseases; Anti-oxidants; Diabetic cardiomyopathy; Oxidative stress
• ISSN: 2040-1116; 2040-1124
• DOI: 10.1111/jdi.12250

Diabetic cardiomyopathy as an important threat to health occurs with or without coexistence of vascular diseases. The exact mechanisms underlying the disease remain incompletely clear. Although several pathological mechanisms responsible for diabetic cardiomyopathy have been proposed, oxidative stress is widely considered as one of the major causes for the pathogenesis of the disease. Hyperglycemia‐, hyperlipidemia‐, hypertension‐ and inflammation‐induced oxidative stress are major risk factors for the development of microvascular pathogenesis in the diabetic myocardium, which results in abnormal gene expression, altered signal transduction and the activation of pathways leading to programmed myocardial cell deaths. In the present article, we aim to provide an extensive review of the role of oxidative stress and anti‐oxidants in diabetic cardiomyopathy based on our own works and literature information available. Although several pathological mechanisms responsible for diabetic cardiomyopathy have been proposed, oxidative stress is widely considered as one of the major causes for the pathogenesis of the disease. Hyperglycemia‐, hyperlipidelima‐, hypertension‐, and inflammation‐induced oxidative stress is a major risk factor for the development of micro‐vascular pathogenesis in the diabetic myocardium, which results in abnormal gene expression, altered signal transduction, and the activation of pathways leading to programmed myocardial cell deaths.