microRNA在纤维化疾病中的研究进展

microRNA（miRNA）是一类长19～25nt的非编码小分子RNA。通过与靶基因序列的特异性相互作用,在转录后水平调控基因表达,从而参与多种生理和病理过程,包括细胞增生、分化、凋亡及致癌等过程。脏器纤维化是多种因素引起的脏器急性或慢性的病理变化,若得不到有效控制,最终可能发展为脏器衰竭,严重影响人类健康。近年来,miRNA与脏器纤维化的基因表达调控研究日益成为焦点,也为临床靶向治疗脏器纤维化提供了可能性。...

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Bibliographic Details
Published in复旦学报（医学版） Vol. 39; no. 1; pp. 94 - 98
Main Author 封丽莎（综述） 樊晓明（审校）
Format Journal Article
LanguageChinese
Published 复旦大学附属金山医院消化科 上海 200540 2012
Subjects
microRNA
纤维化
细胞外基质
microRNA
细胞外基质
纤维化
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ISSN1672-8467
DOI10.3969/j.issn.1672-8467.2012.01.018

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Summary:microRNA（miRNA）是一类长19～25nt的非编码小分子RNA。通过与靶基因序列的特异性相互作用,在转录后水平调控基因表达,从而参与多种生理和病理过程,包括细胞增生、分化、凋亡及致癌等过程。脏器纤维化是多种因素引起的脏器急性或慢性的病理变化,若得不到有效控制,最终可能发展为脏器衰竭,严重影响人类健康。近年来,miRNA与脏器纤维化的基因表达调控研究日益成为焦点,也为临床靶向治疗脏器纤维化提供了可能性。
Bibliography:microRNA; fibrosis; extracellular matrix
FENG Li-sha,FAN Xiao-ming （Department of Digestive,Jinshan Hospital,Fudan University,Shanghai 200540,China）
miRNAs are small,noncoding RNAs,which are 19 to 25 nucleotides long.They either induce the degradation or repress the translation of target mRNA by completely or uncompetely binding with the 3′-untranslated region（3′-URT） of the target mRNA.miRNAs have been shown to play fundamental roles in diverse biological and pathological processes,including cell proliferation,differentiation,apoptosis and carcinogenesis.A growing body of evidence suggests that miRNAs participate in the fibrotic process in a number of organs including the heart,lung,liver and kidney.In this review,we summarize our current understanding of the role of miRNAs in the development of tissue fibrosis and their potential as novel drug targets.
31-1885/R
ISSN:1672-8467
DOI:10.3969/j.issn.1672-8467.2012.01.018