Pathophysiological and Genetic Aspects of Vascular Calcification

• Published in: Cardiology research and practice Vol. 2020; no. 2020; pp. 1 - 11
• Main Authors: Escobar Guzman, Luis Fernando, Lopes, Neuza Helena Moreira, Escobar Guzman, Cristian Andres
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 2020; Hindawi; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Calcification; Cardiovascular diseases; Genetic aspects; Health aspects; Inflammation; Review; Risk factors
• ISSN: 2090-8016; 2090-0597; 2090-0597
• DOI: 10.1155/2020/5169069

Recent evidence suggests that vascular calcification is an independent cardiovascular risk factor (CRF) of morbidity and mortality. New studies point out the existence of a complex physiopathological mechanism that involves inflammation, oxidation, the release of chemical mediators, and genetic factors that promote the osteochondrogenic differentiation of vascular smooth muscle cells (VSMC). This review will evaluate the main mechanisms involved in the pathophysiology and genetics modulation of the process of vascular calcification. Objective. A systematic review of the pathophysiology factors involved in vascular calcification and its genetic influence was performed. Methods. A systematic review was conducted in the Medline and PubMed databases and were searched for studies concerning vascular calcification using the keywords and studies published until 2020/01 in English. Inclusion Criteria. Studies in vitro, animal models, and humans. These include cohort (both retrospective and prospective cohort studies), case-control, cross-sectional, and systematic reviews. Exclusion Criteria. Studies before 2003 of the existing literature.