Reward-learning and the novelty-seeking personality: a between- and within-subjects study of the effects of dopamine agonists on young Parkinson's patients

• Published in: Brain (London, England : 1878) Vol. 132; no. 9; pp. 2385 - 2395
• Main Authors: Bódi, Nikoletta, Kéri, Szabolcs, Nagy, Helga, Moustafa, Ahmed, Myers, Catherine E., Daw, Nathaniel, Dibó, György, Takáts, Annamária, Bereczki, Dániel, Gluck, Mark A.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.09.2009; Oxford Publishing Limited (England)
• Subjects: Adult; Avoidance Learning - drug effects; Benzothiazoles - pharmacology; Benzothiazoles - therapeutic use; Biological and medical sciences; Cross-Sectional Studies; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; dopamine; Dopamine Agonists - pharmacology; Dopamine Agonists - therapeutic use; Exploratory Behavior - drug effects; Feedback, Psychological - drug effects; Female; Follow-Up Studies; Humans; Indoles - pharmacology; Indoles - therapeutic use; Learning - drug effects; Male; Medical sciences; Middle Aged; Neurology; novelty seeking; Original; Parkinson Disease - drug therapy; Parkinson Disease - psychology; Parkinson's disease; Personality; Personality Assessment; pramipexole; Reward; ropinirole; reward; Parkinson's disease; ropinirole; pramipexole; dopamine; novelty seeking; Human; Nervous system diseases; Dopamine; Parkinson disease; Personality; Catecholamine; Pramipexole; Cerebral disorder; Learning; Ropinirole; Acquisition process; Central nervous system disease; Dopamine agonist; Neurotransmitter; Degenerative disease; Extrapyramidal syndrome; Novelty

Parkinson's disease is characterized by the degeneration of dopaminergic pathways projecting to the striatum. These pathways are implicated in reward prediction. In this study, we investigated reward and punishment processing in young, never-medicated Parkinson's disease patients, recently...