Reward-learning and the novelty-seeking personality: a between- and within-subjects study of the effects of dopamine agonists on young Parkinson's patients

• Published in: Brain (London, England : 1878) Vol. 132; no. 9; pp. 2385 - 2395
• Main Authors: Bódi, Nikoletta, Kéri, Szabolcs, Nagy, Helga, Moustafa, Ahmed, Myers, Catherine E., Daw, Nathaniel, Dibó, György, Takáts, Annamária, Bereczki, Dániel, Gluck, Mark A.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.09.2009; Oxford Publishing Limited (England)
• Subjects: Adult; Avoidance Learning - drug effects; Benzothiazoles - pharmacology; Benzothiazoles - therapeutic use; Biological and medical sciences; Cross-Sectional Studies; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; dopamine; Dopamine Agonists - pharmacology; Dopamine Agonists - therapeutic use; Exploratory Behavior - drug effects; Feedback, Psychological - drug effects; Female; Follow-Up Studies; Humans; Indoles - pharmacology; Indoles - therapeutic use; Learning - drug effects; Male; Medical sciences; Middle Aged; Neurology; novelty seeking; Original; Parkinson Disease - drug therapy; Parkinson Disease - psychology; Parkinson's disease; Personality; Personality Assessment; pramipexole; Reward; ropinirole; reward; Parkinson's disease; ropinirole; pramipexole; dopamine; novelty seeking; Human; Nervous system diseases; Dopamine; Parkinson disease; Personality; Catecholamine; Pramipexole; Cerebral disorder; Learning; Ropinirole; Acquisition process; Central nervous system disease; Dopamine agonist; Neurotransmitter; Degenerative disease; Extrapyramidal syndrome; Novelty
• ISSN: 0006-8950; 1460-2156; 1460-2156
• DOI: 10.1093/brain/awp094

Parkinson's disease is characterized by the degeneration of dopaminergic pathways projecting to the striatum. These pathways are implicated in reward prediction. In this study, we investigated reward and punishment processing in young, never-medicated Parkinson's disease patients, recently medicated patients receiving the dopamine receptor agonists pramipexole and ropinirole and healthy controls. The never-medicated patients were also re-evaluated after 12 weeks of treatment with dopamine agonists. Reward and punishment processing was assessed by a feedback-based probabilistic classification task. Personality characteristics were measured by the temperament and character inventory. Results revealed that never-medicated patients with Parkinson's disease showed selective deficits on reward processing and novelty seeking, which were remediated by dopamine agonists. These medications disrupted punishment processing. In addition, dopamine agonists increased the correlation between reward processing and novelty seeking, whereas these drugs decreased the correlation between punishment processing and harm avoidance. Our finding that dopamine agonist administration in young patients with Parkinson's disease resulted in increased novelty seeking, enhanced reward processing, and decreased punishment processing may shed light on the cognitive and personality bases of the impulse control disorders, which arise as side-effects of dopamine agonist therapy in some Parkinson's disease patients.