HPA axis and aging in depression: Systematic review and meta-analysis

• Published in: Psychoneuroendocrinology Vol. 41; pp. 46 - 62
• Main Authors: Belvederi Murri, Martino, Pariante, Carmine, Mondelli, Valeria, Masotti, Mattia, Atti, Anna Rita, Mellacqua, Zefiro, Antonioli, Marco, Ghio, Lucio, Menchetti, Marco, Zanetidou, Stamatula, Innamorati, Marco, Amore, Mario
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.03.2014; Elsevier
• Subjects: ACTH; Adrenocorticotropic Hormone - metabolism; Adult and adolescent clinical studies; Aging - physiology; Aging - psychology; Antidepressant; Behavioral psychophysiology; Biological and medical sciences; Corticotropin-Releasing Hormone - metabolism; Cortisol; CRH; Depression; Depression - metabolism; Depression - physiopathology; Depressive symptoms; Dexamethasone; Elderly; Endocrinology & Metabolism; Fundamental and applied biological sciences. Psychology; Hormones and behavior; HPA axis; Humans; Hydrocortisone - metabolism; Hypothalamo-Hypophyseal System - physiopathology; Medical sciences; Miscellaneous; Mood disorders; Neuropharmacology; Older adults; Pharmacology. Drug treatments; Pituitary-Adrenal Function Tests; Pituitary-Adrenal System - physiopathology; Psychiatry; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Psychopathology. Psychiatry; Psychopharmacology; Antidepressant; Dexamethasone; ACTH; CRH; Depression; Depressive symptoms; Cortisol; HPA axis; Elderly; Older adults; Senescence; Hypothalamohypophysoadrenal axis; Psychotropic; Corticotropin releasing factor; Review; Hydrocortisone; Glucocorticoid; Metaanalysis; Antidepressant agent; Hormone releasing factor; Human; Mood disorder; Corticosteroid; Steroid hormone; Antiinflammatory agent; Hypothalamic hormone; Symptomatology; Adrenocorticotropic hormone; Adenohypophyseal hormone; Adrenal hormone

One of the most consistent findings in the biology of depression is an altered activity of the hypothalamic–pituitary–adrenal (HPA) axis. However, data concerning this issue have never been examined with a focus on the older population. Here we present a systematic review and meta-analysis, based on...