Preventive Effect of Quercetin in a Triple Transgenic Alzheimer's Disease Mice Model

• Published in: Molecules (Basel, Switzerland) Vol. 24; no. 12; p. 2287
• Main Authors: Paula, Pérez-Corredor, Angelica Maria, Sabogal-Guáqueta, Luis, Carrillo-Hormaza, Gloria Patricia, Cardona-Gómez
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 20.06.2019; MDPI
• Subjects: Age; Alzheimer Disease - drug therapy; Alzheimer Disease - genetics; Alzheimer Disease - pathology; Alzheimer Disease - prevention & control; Alzheimer's disease; Amygdala; Amyloid beta-Peptides - genetics; Amyloid beta-Protein Precursor - genetics; Animal cognition; Animals; Antioxidants; Apoptosis; Behavior; Brain - drug effects; Brain - pathology; Cancer; Cognition Disorders - drug therapy; Cognition Disorders - genetics; Cognition Disorders - pathology; Cognition Disorders - prevention & control; Cognitive ability; Cytotoxicity; Dementia; Dementia disorders; Diabetes mellitus; Disease; Disease Models, Animal; Disease prevention; Hippocampus - drug effects; Hippocampus - pathology; Humans; Immunoreactivity; Inflammation; Latency; Lipid peroxidation; Lipids; Maze Learning - drug effects; Memory; Mice; Mice, Transgenic; Neurodegeneration; Oxidation; Oxidative stress; Peroxidation; prevention; Quercetin; Quercetin - pharmacology; tau Proteins - genetics; Transgenic mice; Alzheimer’s disease; quercetin; prevention
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules24122287

Alzheimer's disease (AD) is the most common type of dementia and is the leading cause of disability in elderly people worldwide. Current pharmacological therapies do not cure the disease, and for this reason, some pharmacotherapy studies have investigated preventive treatments focused on modifiable nutritional factors such as diet. Quercetin (Qc) is a flavonoid found in fruits and vegetables that has several biological properties. In this study, we evaluated the effect of chronic oral quercetin administration (100 mg/kg) on neurodegeneration markers and cognitive and emotional deficits in a triple transgenic Alzheimer's disease (3xTg-AD) mouse model using histological and behavioral analyses. Our results suggest that long-term (12 months) oral preventive treatment with quercetin has significant effects on β-amyloidosis reduction and tends to decrease tauopathy in the hippocampus and amygdala. These decreases positively affected the cognitive functional recovery (without modifying the emotional skills) of 3xTg-AD mice. These findings suggest that preventive and chronic administration of Qc might help to delay the development of histopathological hallmarks and cognitive function deficits in AD.