The Human Microbiota in Health and Disease
Trillions of microbes have evolved with and continue to live on and within human beings. A variety of environmental factors can affect intestinal microbial imbalance, which has a close relationship with human health and disease. Here, we focus on the interactions between the human microbiota and the...
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Published in | Engineering (Beijing, China) Vol. 3; no. 1; pp. 71 - 82 |
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Main Authors | , , , , |
Format | Journal Article |
Language | Chinese English |
Published |
Elsevier Ltd
01.02.2017
National Colaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Afiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | Trillions of microbes have evolved with and continue to live on and within human beings. A variety of environmental factors can affect intestinal microbial imbalance, which has a close relationship with human health and disease. Here, we focus on the interactions between the human microbiota and the host in order to provide an overview of the microbial role in basic biological processes and in the develop- ment and progression of major human diseases such as infectious diseases, liver diseases, gastrointesti- nal cancers, metabolic diseases, respiratory diseases, mental or psychological diseases, and autoimmune diseases. We also review important advances in techniques associated with microbial research, such as DNA sequencing, metabonomics, and proteomics combined with computation-based bioinformatics. Current research on the human microbiota has become much more sophisticated and more comprehensive. Therefore, we propose that research should focus on the host-microbe interaction and on causeeffect mechanisms, which could pave the way to an understanding of the role of gut microbiota in health and disease, and provide new therapeutic targets and treatment approaches in clinical practice. |
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Bibliography: | 10-1244/N Microbiome HealthInfectious disease Liver diseases Gastrointestinal malignancy Metabolic disorder Microhiota technology Probiotics Trillions of microbes have evolved with and continue to live on and within human beings. A variety of environmental factors can affect intestinal microbial imbalance, which has a close relationship with human health and disease. Here, we focus on the interactions between the human microbiota and the host in order to provide an overview of the microbial role in basic biological processes and in the develop- ment and progression of major human diseases such as infectious diseases, liver diseases, gastrointesti- nal cancers, metabolic diseases, respiratory diseases, mental or psychological diseases, and autoimmune diseases. We also review important advances in techniques associated with microbial research, such as DNA sequencing, metabonomics, and proteomics combined with computation-based bioinformatics. Current research on the human microbiota has become much more sophisticated and more comprehensive. Therefore, we propose that research should focus on the host-microbe interaction and on causeeffect mechanisms, which could pave the way to an understanding of the role of gut microbiota in health and disease, and provide new therapeutic targets and treatment approaches in clinical practice. |
ISSN: | 2095-8099 |
DOI: | 10.1016/J.ENG.2017.01.008 |