DDB1 maintains intestinal homeostasis by preventing cell cycle arrest

• Published in: Cell regeneration Vol. 11; no. 1; pp. 18 - 4
• Main Authors: Zhao, Lianzheng, Liao, Hongwei, Wang, Xiaodan, Chen, Ye-Guang
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 01.06.2022; Springer Nature B.V; SpringerOpen
• Subjects: Animal models; Apoptosis; Biomedical and Life Sciences; Biomedicine; Cell Biology; Cell cycle; Cell death; Cell growth; Cell proliferation; Cyclin-dependent kinases; DDB1; Epithelium; G1 phase; Homeostasis; Intestine; Kinases; Large intestine; Letter; Life Sciences; Organoids; Proteins; Regenerative medicine; Small intestine; Stem Cells; DDB1; Homeostasis; Intestine; Cell cycle

Before the tissue collapse at day 4, the Ki67+ proliferating cells in the transient amplifying region of crypts were already decreased in the small intestine (Fig. 1D, S3A and S3B), while this change was delayed in the large intestine at day 6 (Fig. [...]the TUNEL assay revealed that cell death was...