Interplay of Hippocampus and Prefrontal Cortex in Memory

Recent studies on the hippocampus and the prefrontal cortex have considerably advanced our understanding of the distinct roles of these brain areas in the encoding and retrieval of memories, and of how they interact in the prolonged process by which new memories are consolidated into our permanent s...

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Bibliographic Details
Published inCurrent biology Vol. 23; no. 17; pp. R764 - R773
Main Authors Preston, Alison R., Eichenbaum, Howard
Format Journal Article
LanguageEnglish
Published England Elsevier Inc 09.09.2013
Subjects
Animals
cortex
hippocampus
Hippocampus - physiology
Humans
memory
Memory - physiology
Prefrontal Cortex - physiology
Rodentia - physiology
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Summary:Recent studies on the hippocampus and the prefrontal cortex have considerably advanced our understanding of the distinct roles of these brain areas in the encoding and retrieval of memories, and of how they interact in the prolonged process by which new memories are consolidated into our permanent storehouse of knowledge. These studies have led to a new model of how the hippocampus forms and replays memories and how the prefrontal cortex engages representations of the meaningful contexts in which related memories occur, as well as how these areas interact during memory retrieval. Furthermore, they have provided new insights into how interactions between the hippocampus and prefrontal cortex support the assimilation of new memories into pre-existing networks of knowledge, called schemas, and how schemas are modified in this process as the foundation of memory consolidation.
Bibliography:http://dx.doi.org/10.1016/j.cub.2013.05.041
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ISSN:0960-9822
1879-0445
DOI:10.1016/j.cub.2013.05.041