Homologous recombination and the repair of DNA double-strand breaks

Homologous recombination enables the cell to access and copy intact DNA sequence information in trans, particularly to repair DNA damage affecting both strands of the double helix. Here, we discuss the DNA transactions and enzymatic activities required for this elegantly orchestrated process in the...

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Published inThe Journal of biological chemistry Vol. 293; no. 27; pp. 10524 - 10535
Main Authors Wright, William Douglass, Shah, Shanaya Shital, Heyer, Wolf-Dietrich
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 06.07.2018
American Society for Biochemistry and Molecular Biology
Subjects
Animals
DNA Breaks, Double-Stranded
DNA damage
DNA endonuclease
DNA helicase
DNA polymerase
DNA recombination
DNA Repair
DNA Replication
DNA topoisomerase
DNA topology
genomic instability
Homologous Recombination
Humans
Signal Transduction
Thematic Minireviews
DNA helicase
DNA topology
DNA polymerase
DNA damage
DNA endonuclease
DNA topoisomerase
genomic instability
DNA recombination
DNA repair
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Summary:Homologous recombination enables the cell to access and copy intact DNA sequence information in trans, particularly to repair DNA damage affecting both strands of the double helix. Here, we discuss the DNA transactions and enzymatic activities required for this elegantly orchestrated process in the context of the repair of DNA double-strand breaks in somatic cells. This includes homology search, DNA strand invasion, repair DNA synthesis, and restoration of intact chromosomes. Aspects of DNA topology affecting individual steps are highlighted. Overall, recombination is a dynamic pathway with multiple metastable and reversible intermediates designed to achieve DNA repair with high fidelity.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
Edited by Patrick Sung
ISSN:0021-9258
1083-351X
DOI:10.1074/jbc.TM118.000372