Changes in the Development of Striatum Are Involved in Repetitive Behavior in Autism

• Published in: Biological psychiatry (1969) Vol. 76; no. 5; pp. 405 - 411
• Main Authors: Langen, Marieke, Bos, Dienke, Noordermeer, Siri D.S., Nederveen, Hilde, van Engeland, Herman, Durston, Sarah
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.09.2014; Elsevier
• Subjects: Adolescent; Autism; Autistic Disorder - pathology; Biological and medical sciences; Brain - growth & development; Brain - pathology; brain development; Child; Child clinical studies; Corpus Striatum - growth & development; Corpus Striatum - pathology; corticostriatal circuitry; Developmental disorders; Female; Functional Laterality; Humans; Infantile autism; insistence on sameness; Longitudinal Studies; Magnetic Resonance Imaging; Male; Medical sciences; Multivariate Analysis; Organ Size; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; repetitive behavior; Stereotyped Behavior; striatum; brain development; corticostriatal circuitry; insistence on sameness; Autism; repetitive behavior; striatum; Central nervous system; Development; Basal ganglion; Developmental disorder; Corpus striatum; Repetitive behavior; Encephalon
• ISSN: 0006-3223; 1873-2402; 1873-2402
• DOI: 10.1016/j.biopsych.2013.08.013

Repetitive behavior is a core feature of autism and has been linked to differences in striatum. In addition, the brain changes associated with autism appear to vary with age. However, most studies investigating striatal differences in autism are cross-sectional, limiting inferences on development. In this study, we set out to 1) investigate striatal development in autism, using a longitudinal design; and 2) examine the relationship between striatal development and repetitive behavior. We acquired longitudinal structural magnetic resonance imaging scans from 86 individuals (49 children with autism, 37 matched control subjects). Each individual was scanned twice, with a mean scan interval time of 2.4 years. Mean age was 9.9 years at time 1 and 12.3 years at time 2. Striatal structures were traced manually with high reliability. Multivariate analyses of variance were used to investigate differences in brain development between diagnostic groups. To examine the relationship with behavior, correlations between changes in brain volumes and clinical measures were calculated. Our results showed an increase in the growth rate of striatal structures for individuals with autism compared with control subjects. The effect was specific to caudate nucleus, where growth rate was doubled. Second, faster striatal growth was correlated with more severe repetitive behavior (insistence on sameness) at the preschool age. This longitudinal study of brain development in autism confirms the involvement of striatum in repetitive behavior. Furthermore, it underscores the significance of brain development in autism, as the severity of repetitive behavior was related to striatal growth, rather than volume per se.