The influence of synaptic activity on neuronal health

Research highlights ▶ This review focuses on activity dependent events that boost neuronal health. ▶ The following ways through which activity boosts neuronal health will be discussed: transcriptional control of pro-apoptotic and anti-apoptotic genes; enhanced antioxidant defences; regulation of mit...

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Published inCurrent opinion in neurobiology Vol. 21; no. 2; pp. 299 - 305
Main Authors Bell, Karen FS, Hardingham, Giles E
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.04.2011
Subjects
Animals
Antioxidants
Humans
Neurodegenerative Diseases - physiopathology
Neurology
Neurons - pathology
Neurons - physiology
Psychiatry
Signal Transduction - physiology
Synapses - pathology
Synapses - physiology
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Summary:Research highlights ▶ This review focuses on activity dependent events that boost neuronal health. ▶ The following ways through which activity boosts neuronal health will be discussed: transcriptional control of pro-apoptotic and anti-apoptotic genes; enhanced antioxidant defences; regulation of mitochondrial and growth factor availability. ▶ We also discuss events where neuronal activity influences events specific to individual neurodegenerative diseases.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0959-4388
1873-6882
DOI:10.1016/j.conb.2011.01.002