非酒精性脂肪性肝病动物实验模型研究进展

近年来随着肥胖、2型糖尿病、高脂血症等发生率的升高,非酒精性脂肪性肝病（NAFLD）的发病率也逐渐升高,成为常见的慢性肝脏疾病之一,而在我国是仅次于慢性病毒性肝炎的第二大肝病。但其发病机制仍未阐明,因NAFLD的发生和演进病程长,且从人体获取肝组织进行研究或药物试验等受伦理限制,因此NAFLD动物模型在本病研究中起了重要作用。综述了具备与NAFLD患者组织病理学表现相似的动物模型,并比较其建模原理及优缺点。为深入研究NAFLD发病机制,筛选防治药物等提供了有利工具。...

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Published in临床肝胆病杂志 Vol. 30; no. 9; pp. 948 - 953
Main Author 黄海燕 辛永宁 姜曼 金文文 姜相君 宣世英
Format Journal Article
LanguageChinese
Published 泰山医学院,山东 泰安,271016%青岛市市立医院 消化内二科，山东 青岛266021 2014
青岛市消化疾病重点实验室，山东 青岛266021%青岛市消化疾病重点实验室,山东 青岛,266021%青岛市市立医院 消化内二科,山东 青岛,266021
Subjects
小鼠
疾病模型,动物
综述
脂肪肝
脂肪肝
review
小鼠
fatty liver
综述
mice
disease models,animal
疾病模型,动物
Online AccessGet full text
ISSN1001-5256
DOI10.3969/j.issn.1001-5256.2014.09.028

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Summary:近年来随着肥胖、2型糖尿病、高脂血症等发生率的升高,非酒精性脂肪性肝病（NAFLD）的发病率也逐渐升高,成为常见的慢性肝脏疾病之一,而在我国是仅次于慢性病毒性肝炎的第二大肝病。但其发病机制仍未阐明,因NAFLD的发生和演进病程长,且从人体获取肝组织进行研究或药物试验等受伦理限制,因此NAFLD动物模型在本病研究中起了重要作用。综述了具备与NAFLD患者组织病理学表现相似的动物模型,并比较其建模原理及优缺点。为深入研究NAFLD发病机制,筛选防治药物等提供了有利工具。
Bibliography:fatty liver; disease models; animal; mice; review
HUANG Haiyan , XIN Yongning , JIANG Man, et al （Taishan Medical University, Taian , Shandong 271016, China）
In recent years,the incidence of nonalcoholic fatty liver disease（ NAFLD） has increased gradually along with the rising prevalence of obesity,type 2 diabetes,and hyperlipidemia,and NAFLD has become one of the most common chronic liver diseases in the world and the second major liver disease after chronic viral hepatitis in China. However,its pathogenesis has not yet been clarified. Animal models are playing an important role in researches on NAFLD due to the facts that the development and progression of NAFLD require a long period of time,and ethical limitations exist in conducting drug trials in patients or collecting liver tissues from patients. The animal models with histopathology similar to that of NAFLD patients are reviewed,and their modeling principle,as well as the advantages and disadvantages,are compared. Animal models provide a powerful tool fo
ISSN:1001-5256
DOI:10.3969/j.issn.1001-5256.2014.09.028