microRNA在慢性乙型肝炎肝纤维化中的诊断价值

寻找能够准确识别慢性乙型肝炎（CHB）肝纤维化的血清标志物十分重要。归纳了在CHB肝纤维化过程中存在表达差异的microRNA（miRNA）,分析表明随着肝纤维化发展,血清miR-33a、miR-185、miR-222等表达量升高,而血清miR-122、miR-29、miR-27b等表达量下降。发现血清miR-185、miR-122等miRNA单独或联合其他指标在诊断CHB肝纤维化中已具有一定的临床应用价值。认为应进一步加大对存在差异表达的具有诊断CHB肝纤维化价值的血清miRNA的研究。...

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Bibliographic Details
Published in临床肝胆病杂志 Vol. 33; no. 12; pp. 2412 - 2415
Main Author 李萍英;杨永耿;陆伦根;朱智勇;王亚平;马颖才
Format Journal Article
LanguageChinese
Published 青海大学,西宁810016 2017
青海省人民医院消化科,西宁810007%青海省人民医院消化科,西宁,810007%上海交通大学附属第一人民医院 消化科,上海,200080
Subjects
微RNAs
综述
肝炎,乙型,慢性
肝硬化
microRNAs
肝炎,乙型,慢性
hepatitis B
肝硬化
review
综述
chronic
liver cirrhosis
微RNAs
Online AccessGet full text
ISSN1001-5256
DOI10.3969/j.issn.1001-5256.2017.12.036

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Summary:寻找能够准确识别慢性乙型肝炎（CHB）肝纤维化的血清标志物十分重要。归纳了在CHB肝纤维化过程中存在表达差异的microRNA（miRNA）,分析表明随着肝纤维化发展,血清miR-33a、miR-185、miR-222等表达量升高,而血清miR-122、miR-29、miR-27b等表达量下降。发现血清miR-185、miR-122等miRNA单独或联合其他指标在诊断CHB肝纤维化中已具有一定的临床应用价值。认为应进一步加大对存在差异表达的具有诊断CHB肝纤维化价值的血清miRNA的研究。
Bibliography:It is very important to find suitable serum markers which can accurately identify chronic hepatitis B（ CHB）-related liver fibrosis. This article summarizes the differentially expressed serum microRNAs（ miRNAs） in the process of CHB-related liver fibrosis. The analysis shows that with the development of liver fibrosis,there are increases in the serum levels of miR-33 a,miR-185,and miR-222 and reductions in the serum levels of miR-122,miR-29,and miR-27 b. It has been found that miRNAs such as miR-185 and miR-122 measured alone or in combination with other indices have a certain clinical value in the diagnosis of CHB-related liver fibrosis. It is pointed out that further research should be conducted for differentially expressed serum miRNAs which have a certain value in the diagnosis of CHB-related liver fibrosis.
LI Pingying, YANG Yonggeng, LU Lungen, et al. （ Qinghai University, Xining 810016, China）
hepatitis B, chronic ; microRNAs ; liver cirrhosis ; review
22-1108/R
ISSN:1001-5256
DOI:10.3969/j.issn.1001-5256.2017.12.036