语义性痴呆结构性磁共振成像研究

目的分析语义性痴呆患者灰质和白质结构变化，提高对其病理改变和发生机制的认识。方法采用3．0TMRI扫描仪对16例语义性痴呆患者和17例正常对照者进行全脑扫描，扫描序列包括三维高分辨力结构像和扩散张量成像（DTI）。通过专业统计软件分别对全脑灰质密度和白质纤维束部分各向异性（FA）值进行分析，比较两组受试者全脑灰质密度（P〈O．001，Voxel〉338）和白质纤维束FA值（P〈0．005，Voxel〉103）。结果与对照组相比，语义性痴呆组患者双侧颞叶，特别是颞极表现为灰质密度显著降低，以左侧大脑半球额颞顶叶灰质密度减低区域更为广泛，包括左侧颞下回、缘上回、顶下回和额中回；同时双侧颞叶自质纤维...

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Published in中国现代神经疾病杂志 Vol. 14; no. 4; pp. 298 - 302
Main Author 赵铮 杨延辉 卢春明 周爱红 李坤成
Format Journal Article
LanguageChinese
Published 首都医科大学宣武医院放射科磁共振成像脑信息学北京市重点实验室 神经变性病教育部重点实验室, 北京,100053%100875,北京师范大学认知神经科学与学习国家重点实验室IDG/麦戈文脑科学研究院%首都医科大学宣武医院神经内科, 北京,100053 2014
Subjects
痴呆
磁共振成像
额叶
颞叶
Temporal lobe
Frontal lobe
磁共振成像
Magnetic resonance imaging
颞叶
额叶
痴呆
Dementia
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ISSN1672-6731
DOI10.3969/j.issn.1672-6731.2014.04.007

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Summary:目的分析语义性痴呆患者灰质和白质结构变化，提高对其病理改变和发生机制的认识。方法采用3．0TMRI扫描仪对16例语义性痴呆患者和17例正常对照者进行全脑扫描，扫描序列包括三维高分辨力结构像和扩散张量成像（DTI）。通过专业统计软件分别对全脑灰质密度和白质纤维束部分各向异性（FA）值进行分析，比较两组受试者全脑灰质密度（P〈O．001，Voxel〉338）和白质纤维束FA值（P〈0．005，Voxel〉103）。结果与对照组相比，语义性痴呆组患者双侧颞叶，特别是颞极表现为灰质密度显著降低，以左侧大脑半球额颞顶叶灰质密度减低区域更为广泛，包括左侧颞下回、缘上回、顶下回和额中回；同时双侧颞叶自质纤维束FA值显著降低，包括双侧钩束、左侧扣带（海马）纤维和双侧下额枕束。白质纤维束FA值分析结果与VBM法所显示的灰质密度在解剖学上呈现极高的一致性。结论本研究在体揭示了语义性痴呆的病理学和解剖学基础，为理解语义性痴呆的病理学机制提供了客观佐证。
Bibliography:Objective To analyze the structural changes of cerebral gray and white matter in patients with semantic dementia （SD）, and to promote the knowledge of its pathological changes and meehanisms. Methods Sixteen SD patients and 17 normal controls were scanned with a 3.0T MR scanner and the whole brain three-dimensional high-resolution structural images and diffusion tensor imaging （DTI） images were acquired. The gray matter density and fractional anisotropy （FA） values of white matter fiber tracts were analyzed by professional statistical softwares or packages respectively. The statistical analysis of gray matter density and FA values between 2 groups were processed by two sample t test, and the statistical threshold were set as P 〈 0.001, Voxel 〉 338 and P 〈 0.001, Voxel 〉 103 respectively. Results Compared with the healthy controls, SD patients appeared significantly reduced gray matter density in bilateral temporal lobes, particularly in temporal pole. In addition, SD group showed more areas with grey matter l
ISSN:1672-6731
DOI:10.3969/j.issn.1672-6731.2014.04.007