Avenanthramide C suppresses hypoxia-induced cyclooxygenase-2 expression through sirtuin1 activation in non-small-cell lung cancer cells

• Published in: Animal cells and systems Vol. 24; no. 2; pp. 79 - 83
• Main Authors: Lim, Wonchung, Kang, Chounghun
• Format: Journal Article
• Language: English
• Published: Daejeon Taylor & Francis 03.03.2020; Taylor & Francis Ltd; Taylor & Francis Group; 한국통합생물학회
• Subjects: anti-inflammatory activity; Avenanthramide C; avenanthramides; Cell activation; Cyclooxygenase-2; Cytokines; Hypoxia; Inflammation; Lung cancer; lung neoplasms; lungs; Molecular Cellular Biology; neoplasm cells; Non-small cell lung carcinoma; oats; prostaglandin synthase; protein content; SIRT1; SIRT1 protein; 생물학
• ISSN: 1976-8354; 2151-2485; 2151-2485
• DOI: 10.1080/19768354.2020.1748108

Avenanthramide C (AVC), found mainly in oats, mediates anti-inflammatory activities by reducing the anti-inflammatory cytokine levels. This study investigated the effects of AVC on hypoxia-induced cyclooxygenase-2 (COX-2) expression in A549 cells. AVC suppressed the hypoxia-induced increase in COX-2 protein levels and promoter activity. We also observed that the effects of AVC were reversed by a SIRT1 inhibitor, indicating that the inhibitory effects of AVC on hypoxia-induced COX-2 expression are mediated by SIRT1. Therefore, AVC inhibits the hypoxic induction of COX-2 expression via SIRT1 activation. Our results suggest that AVC could be beneficial for preventing lung inflammation under hypoxia.