Tunable infrared metamaterial-based biosensor for detection of hemoglobin and urine using phase change material

• Published in: Scientific reports Vol. 11; no. 1; p. 7101
• Main Authors: Patel, Shobhit K., Parmar, Juveriya, Sorathiya, Vishal, Nguyen, Truong Khang, Dhasarathan, Vigneswaran
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 29.03.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 639/624/1075/1083; 639/624/399/1015; Alloys - chemistry; Biosensing Techniques; Biosensors; Equipment Design; Hemoglobin; Hemoglobins - analysis; Humanities and Social Sciences; Humans; Limit of Detection; multidisciplinary; Refractometry; Science; Science (multidisciplinary); Spectrum Analysis - methods; Urinalysis - instrumentation
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-021-86700-6

This paper reports about the outcomes from an investigation carried out on tunable biosensor for detection using infrared in the range of 1.5 µm and 1.65 µm. The biosensor is made of phase change material formed by different alloy combinations, Ge 2 Sb 2 Te 5 (GST). The nature of GST allows for the material to change phase with changes in temperature, giving the tunable sensing property for biosensing application. Sensor built with amorphous GST (aGST) and crystalline GST (cGST) in different design structures were tested on different concentrations of biomolecules: hemoglobin (10 g/l, 20 g/l, 30 g/l and 40 g/l); and urine (0–1.5 mg/dL, 2.5 mg/dL, 5 mg/dL and 10 mg/dL). The tunable response observed from the tests demonstrates the potential application of the materials in the design of switching and sensing systems.