INACTIVATION OF FUSIDIC ACID BY RESISTANT Streptomyces STRAINS

Streptomyces lividans and several other Streptomyces species are resistant to the steroid-like antibiotic fusidic acid. This resistance is mediated by structural modification of the antibiotic. Using TLC, CD, UV, IR, NMR and mass spectroscopy the structure of one of the resulting inactive compounds...

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Bibliographic Details
Published inJournal of antibiotics Vol. 44; no. 7; pp. 785 - 792
Main Authors HAAR, BEATE VON DER, ROSENBERG, DOUWE, DITTRICH, WERNER, SCHREMPF, HILDGUND
Format Journal Article
LanguageEnglish
Published Tokyo JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 1991
Japan Antibiotics Research Association
Subjects
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Chromatography, Thin Layer
Drug Resistance, Microbial
Fusidic Acid - analogs & derivatives
Fusidic Acid - chemistry
Fusidic Acid - metabolism
Fusidic Acid - pharmacology
Magnetic Resonance Spectroscopy
Mass Spectrometry
Medical sciences
Molecular Structure
Pharmacology. Drug treatments
Spectrophotometry, Infrared
Streptomyces - drug effects
Streptomyces - metabolism
Actinomycetales
Antibiotic
Streptomycetaceae
Metabolite
Metabolic inactivation
Microorganism culture
Streptomyces
Bacteria
Actinomycetes
Metabolism
In vitro
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Summary:Streptomyces lividans and several other Streptomyces species are resistant to the steroid-like antibiotic fusidic acid. This resistance is mediated by structural modification of the antibiotic. Using TLC, CD, UV, IR, NMR and mass spectroscopy the structure of one of the resulting inactive compounds was determined. It is derived from fusidic acid by the loss of an acetyl group and the formation of a lactone ring between C-21 and C-16. In addition, helvolic acid, a compound closely related to fusidic acid, has been shown to be modified.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.44.785