Immunochemical Measurement of Placental Tissue Protein 4 in Serum
Using the avidin-biotin binding system, an enzyme immunoassay procedure was developed to measure the placental tissue protein 4 (PP4) in serum. The standard curve covered the range from 0.5 to 100 ng/ml of PP4. The intra- and inter-assay coefficients of variation were less than 5 and 10%, respective...
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| Published in | Chemical & pharmaceutical bulletin Vol. 34; no. 5; pp. 2191 - 2195 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Tokyo
The Pharmaceutical Society of Japan
1986
Maruzen Japan Science and Technology Agency |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0009-2363 1347-5223 |
| DOI | 10.1248/cpb.34.2191 |
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| Abstract | Using the avidin-biotin binding system, an enzyme immunoassay procedure was developed to measure the placental tissue protein 4 (PP4) in serum. The standard curve covered the range from 0.5 to 100 ng/ml of PP4. The intra- and inter-assay coefficients of variation were less than 5 and 10%, respectively. Recoveries of PP4 added to serum ranged between about 99 and 105%. The result obtained by this assay method correlated well with those obtained by the radioimmunoassay method. The PP4 serum leve was under 10 ng/ml in non-pathological individuals. In pregnancies during 5-40 weeks, the level ranged from 0.9 to 15.0 ng/ml. In ovarian malignancies, the PP4 concentration in serum irrespectively scattered from 0.9 to 21 ng/ml. Significantly high PP4 levels were found in uterine cervical cancer in the early stage and also in endometrial cancer. |
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| AbstractList | Using the avidin-biotin binding system, an enzyme immunoassay procedure was developed to measure the placental tissue protein 4 (PP4) in serum. The standard curve covered the range from 0.5 to 100 ng/ml of PP4. The intra- and inter-assay coefficients of variation were less than 5 and 10%, respectively. Recoveries of PP4 added to serum ranged between about 99 and 105%. The result obtained by this assay method correlated well with those obtained by the radioimmunoassay method. The PP4 serum leve was under 10 ng/ml in non-pathological individuals. In pregnancies during 5-40 weeks, the level ranged from 0.9 to 15.0 ng/ml. In ovarian malignancies, the PP4 concentration in serum irrespectively scattered from 0.9 to 21 ng/ml. Significantly high PP4 levels were found in uterine cervical cancer in the early stage and also in endometrial cancer. |
| Author | TAKAMIZAWA, HIROYOSHI SHIROTAKE, SYOICHI INABA, NORIYUKI BOHN, HANS OHTA, YORIKO FUKAZAWA, ICHIO |
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| Cites_doi | 10.1016/S0076-6879(74)34023-2 10.1002/1097-0142(197710)40:4<1621::AID-CNCR2820400435>3.0.CO;2-I 10.7326/0003-4819-78-1-39 |
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| SubjectTerms | Analytical, structural and metabolic biochemistry Annexin A5 Biological and medical sciences endometrial cancer Female Fundamental and applied biological sciences. Psychology Holoproteins Humans Immunoenzyme Techniques Other proteins Pregnancy Pregnancy Proteins - analysis Pregnancy Proteins - blood Proteins Radioimmunoassay |
| Title | Immunochemical Measurement of Placental Tissue Protein 4 in Serum |
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