Efficient Synthesis of a Schiff Base Copper(II) Complex Using a Microfluidic Device

• Published in: Micromachines (Basel) Vol. 14; no. 4; p. 890
• Main Authors: Kobayashi, Masashi, Akitsu, Takashiro, Furuya, Masahiro, Sekiguchi, Tetsushi, Shoji, Shuichi, Tanii, Takashi, Tanaka, Daiki
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 21.04.2023; MDPI
• Subjects: Amino acids; Biological activity; Chemical reactions; Chemical synthesis; Copper; copper complex; Copper compounds; Drug discovery; Experiments; high throughput; Imines; Infrared spectroscopy; Ligands; microfluidic; Microfluidic devices; R&D; Reagents; Research & development; Room temperature; Schiff base; Schiff bases; Japan; Schiff base; copper complex; microfluidic; high throughput
• ISSN: 2072-666X; 2072-666X
• DOI: 10.3390/mi14040890

The efficient synthesis of amino acid Schiff base copper(II) complexes using a microfluidic device was successfully achieved. Schiff bases and their complexes are remarkable compounds due to their high biological activity and catalytic function. Conventionally, products are synthesized under reaction conditions of 40 °C for 4 h using a beaker-based method. However, in this paper, we propose using a microfluidic channel to enable quasi-instantaneous synthesis at room temperature (23 °C). The products were characterized using UV-Vis, FT-IR, and MS spectroscopy. The efficient generation of compounds using microfluidic channels has the potential to significantly contribute to the efficiency of drug discovery and material development due to high reactivity.