Autoradiographic Study on the Distribution of Cyclocytidine in Mice

The distribution of cyclocytidine was investigated by means of whole-body autoradiographic technique following intravenous injection in mice. Significant difference was found in the distribution pattern of radioactivity between cyclocytidine and other cytidine analogues such as aracytidine. Distribu...

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Published inChemical & pharmaceutical bulletin Vol. 22; no. 10; pp. 2311 - 2317
Main Authors HOSHI, AKIO, IIGO, MASAAKI, KURETANI, KAZUO, KANAI, TADASHI, ICHINO, MOTONOBU
Format Journal Article
LanguageEnglish
Published Japan The Pharmaceutical Society of Japan 01.01.1974
Japan Science and Technology Agency
Subjects
Animals
Autoradiography
Central Nervous System - metabolism
Cytarabine - analogs & derivatives
Cytarabine - metabolism
Digestive System - metabolism
Female
Liver - metabolism
Lung - metabolism
Mice
Muscles - metabolism
Time Factors
Urinary Tract - metabolism
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Summary:The distribution of cyclocytidine was investigated by means of whole-body autoradiographic technique following intravenous injection in mice. Significant difference was found in the distribution pattern of radioactivity between cyclocytidine and other cytidine analogues such as aracytidine. Distribution of cyclocytidine was more localized in some organs than that of aracytidine, and was analogous to that of cytidine and not deoxycytidine. Cyclocytidine and aracytidine disappeared almost completely from the body within 24 hr. These two compounds were scarcely incorporated in acid-insoluble components in tissues within 10 min, whereas cytidine and deoxycytidine was rapidly incorporated into nucleic acids and the latter two compounds retained over 24 hr.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.22.2311