NeuroGrid: recording action potentials from the surface of the brain

Recording from neural networks at the resolution of action potentials is critical for understanding how information is processed in the brain. Here, we address this challenge by developing an organic material-based, ultraconformable, biocompatible and scalable neural interface array (the 'Neuro...

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Published inNature neuroscience Vol. 18; no. 2; pp. 310 - 315
Main Authors Khodagholy, Dion, Gelinas, Jennifer N, Thesen, Thomas, Doyle, Werner, Devinsky, Orrin, Malliaras, George G, Buzsáki, György
Format Journal Article
LanguageEnglish
Published United States Nature Publishing Group 01.02.2015
Subjects
Action Potentials - physiology
Animals
Brain mapping
Brain research
Cerebral Cortex - physiology
Electrodes - standards
Electrophysiology - instrumentation
Electrophysiology - methods
Epilepsy - surgery
Humans
Interneurons - physiology
Intraoperative Neurophysiological Monitoring - instrumentation
Intraoperative Neurophysiological Monitoring - methods
Neural circuitry
Physiological aspects
Pyramidal Cells - physiology
Rats
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Summary:Recording from neural networks at the resolution of action potentials is critical for understanding how information is processed in the brain. Here, we address this challenge by developing an organic material-based, ultraconformable, biocompatible and scalable neural interface array (the 'NeuroGrid') that can record both local field potentials(LFPs) and action potentials from superficial cortical neurons without penetrating the brain surface. Spikes with features of interneurons and pyramidal cells were simultaneously acquired by multiple neighboring electrodes of the NeuroGrid, allowing for the isolation of putative single neurons in rats. Spiking activity demonstrated consistent phase modulation by ongoing brain oscillations and was stable in recordings exceeding 1 week's duration. We also recorded LFP-modulated spiking activity intraoperatively in patients undergoing epilepsy surgery. The NeuroGrid constitutes an effective method for large-scale, stable recording of neuronal spikes in concert with local population synaptic activity, enhancing comprehension of neural processes across spatiotemporal scales and potentially facilitating diagnosis and therapy for brain disorders.
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D.K., G.G.M., and G.B. conceived the project. D.K. designed, fabricated, and characterized the devices. D.K. and J.G. did the rodent in vivo experiments. D.K. and J.G. analyzed neural data. D.K., J.G., and T.T. did the intra-operative patient recordings. W.D. was the attending neurosurgeon and supervised the intra-operative recordings. T.T. and O.D. supervised the epilepsy patient recordings and IRB. D.K., J.G., and G.B. wrote the paper with input from the other authors.
Author contributions
ISSN:1097-6256
1546-1726
DOI:10.1038/nn.3905